Enviar artigo por via de e-mail Analysis of racemic conjugates of purine with heterocyclic amines by chiral high-performance liquid chromatography
- Autores: Tumashov A.A.1,2, Gruzdev D.A.1, Vigorov A.Y.1, Musiyak V.V.1, Chulakov E.N.1, Levit G.L.1, Krasnov V.P.1, Charushin V.N.1,3
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Afiliações:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Institute of Natural Sciences and Mathematics, Ural Federal University
- Institute of Chemical Engineering, Ural Federal University
- Edição: Volume 67, Nº 9 (2018)
- Páginas: 1704-1709
- Seção: Article
- URL: https://journal-vniispk.ru/1066-5285/article/view/243018
- DOI: https://doi.org/10.1007/s11172-018-2279-0
- ID: 243018
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Resumo
Reversed-phase HPLC on chiral stationary phases was used to study the influence of the structure of purine and 2-aminopurine conjugates with chiral heterocyclic amines on the retention times. The optimum conditions for separation of enantiomers were found. The best parameters of separation of stereoisomers of all the compounds examined were achieved on a (S,S)-Whelk-O1 column in weakly alkaline aqueous methanol systems.
Sobre autores
A. Tumashov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Institute of Natural Sciences and Mathematics, Ural Federal University
Email: izvan@ioc.ac.ru
Rússia, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002
D. Gruzdev
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: izvan@ioc.ac.ru
Rússia, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990
A. Vigorov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: izvan@ioc.ac.ru
Rússia, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990
V. Musiyak
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: izvan@ioc.ac.ru
Rússia, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990
E. Chulakov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: izvan@ioc.ac.ru
Rússia, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990
G. Levit
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: izvan@ioc.ac.ru
Rússia, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990
V. Krasnov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: izvan@ioc.ac.ru
Rússia, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990
V. Charushin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Institute of Chemical Engineering, Ural Federal University
Email: izvan@ioc.ac.ru
Rússia, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002
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