Analysis of racemic conjugates of purine with heterocyclic amines by chiral high-performance liquid chromatography

A. A. Tumashov; D. A. Gruzdev; A. Yu. Vigorov; V. V. Musiyak; E. N. Chulakov; G. L. Levit; V. P. Krasnov; V. N. Charushin

doi:10.1007/s11172-018-2279-0

Analysis of racemic conjugates of purine with heterocyclic amines by chiral high-performance liquid chromatography

Авторлар: Tumashov A.A.¹^,2, Gruzdev D.A.¹, Vigorov A.Y.¹, Musiyak V.V.¹, Chulakov E.N.¹, Levit G.L.¹, Krasnov V.P.¹, Charushin V.N.¹^,3
Мекемелер:
1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
2. Institute of Natural Sciences and Mathematics, Ural Federal University
3. Institute of Chemical Engineering, Ural Federal University
Шығарылым: Том 67, № 9 (2018)
Беттер: 1704-1709
Бөлім: Article
URL: https://journal-vniispk.ru/1066-5285/article/view/243018
DOI: https://doi.org/10.1007/s11172-018-2279-0
ID: 243018

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Аннотация

Reversed-phase HPLC on chiral stationary phases was used to study the influence of the structure of purine and 2-aminopurine conjugates with chiral heterocyclic amines on the retention times. The optimum conditions for separation of enantiomers were found. The best parameters of separation of stereoisomers of all the compounds examined were achieved on a (S,S)-Whelk-O1 column in weakly alkaline aqueous methanol systems.

Авторлар туралы

A. Tumashov

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Institute of Natural Sciences and Mathematics, Ural Federal University

Email: izvan@ioc.ac.ru
Ресей, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002