Synthesis of ivermectin-4″,5-diyl[bis( N -methylcarbamate)]

A. N. Blinnikov; E. I. Chernoburova; N. G. Kolotyrkina; M. A. Shchetinina; V. A. Lishchuk; K. L. Ovchinnikov; A. V. Kolobov; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

doi:10.1007/s11172-018-2145-0

Synthesis of ivermectin-4″,5-diyl[bis(N-methylcarbamate)]

Autores: Blinnikov A.N.¹, Chernoburova E.I.¹, Kolotyrkina N.G.¹, Shchetinina M.A.¹, Lishchuk V.A.², Ovchinnikov K.L.², Kolobov A.V.², Dzhafarov M.K.², Vasilevich F.I.², Zavarzin I.V.¹
Afiliações:
1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
2. K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Edição: Volume 67, Nº 5 (2018)
Páginas: 833-835
Seção: Full Articles
URL: https://journal-vniispk.ru/1066-5285/article/view/242508
DOI: https://doi.org/10.1007/s11172-018-2145-0
ID: 242508

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Resumo

New ivermectin-4″,5-diyl[bis(N-methylcarbamate)] was synthesized by the MoO₂Cl₂(DMF)₂-catalyzed reaction of ivermectin with methyl isocyanate. The synthesized compound could find application as antiparasitic agent.

Sobre autores

A. Blinnikov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
Rússia, 47 Leninsky prosp., Moscow, 119991

E. Chernoburova

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
Rússia, 47 Leninsky prosp., Moscow, 119991

N. Kolotyrkina

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
Rússia, 47 Leninsky prosp., Moscow, 119991

M. Shchetinina

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
Rússia, 47 Leninsky prosp., Moscow, 119991