Synthesis of ivermectin-4″,5-diyl[bis( N -methylcarbamate)]

A. N. Blinnikov; E. I. Chernoburova; N. G. Kolotyrkina; M. A. Shchetinina; V. A. Lishchuk; K. L. Ovchinnikov; A. V. Kolobov; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

doi:10.1007/s11172-018-2145-0

Synthesis of ivermectin-4″,5-diyl[bis(N-methylcarbamate)]

作者: Blinnikov A.N.¹, Chernoburova E.I.¹, Kolotyrkina N.G.¹, Shchetinina M.A.¹, Lishchuk V.A.², Ovchinnikov K.L.², Kolobov A.V.², Dzhafarov M.K.², Vasilevich F.I.², Zavarzin I.V.¹
隶属关系:
1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
2. K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
期: 卷 67, 编号 5 (2018)
页面: 833-835
栏目: Full Articles
URL: https://journal-vniispk.ru/1066-5285/article/view/242508
DOI: https://doi.org/10.1007/s11172-018-2145-0
ID: 242508

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详细

New ivermectin-4″,5-diyl[bis(N-methylcarbamate)] was synthesized by the MoO₂Cl₂(DMF)₂-catalyzed reaction of ivermectin with methyl isocyanate. The synthesized compound could find application as antiparasitic agent.

作者简介

A. Blinnikov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991

E. Chernoburova

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991

N. Kolotyrkina

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991

M. Shchetinina

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991