Synthesis of 4-aryl-1,7-dihydroxyalkane-2,6-diones under aldol reaction conditions


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Reactions of 3-hydroxyalkan-2-ones with (hetero)aromatic aldehydes under basic conditions lead to 4-aryl-1,7-dihydroxyalkane-2,6-diones. These products were also synthesized by dismutation of 4-aryl-1-hydroxyalk-3-ene-2-ones. The reactions proceed as tandem retro aldol reactions and the Michael addition.

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M. Mavrov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

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