Synthesis and biological activity of arylaliphatic  N -(2-aminoethyl)- N -(2-hydroxy-2-phenylethyl)carboxamides

D. Q. Hoang; E. Ya. Borisova; N. Yu. Borisova; N. Yu. Asilova; O. S. Kaldyrkaeva; E. V. Arzamastsev; O. A. Terekhova; E. Yu. Afanas’eva; E. L. Levitskaya

doi:10.1007/s11172-018-2048-0

Synthesis and biological activity of arylaliphatic N-(2-aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides

作者: Hoang D.Q.¹, Borisova E.Y.¹, Borisova N.Y.¹, Asilova N.Y.¹, Kaldyrkaeva O.S.², Arzamastsev E.V.², Terekhova O.A.², Afanas’eva E.Y.², Levitskaya E.L.²
隶属关系:
1. Moscow Technological University (Institute of Fine Chemical Technology)
2. Russian Cardiology Research and Production Complex
期: 卷 67, 编号 1 (2018)
页面: 131-136
栏目: Article
URL: https://journal-vniispk.ru/1066-5285/article/view/241982
DOI: https://doi.org/10.1007/s11172-018-2048-0
ID: 241982

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详细

N-(2-Aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides were synthesized from styrene oxide by ring opening with N,N-disubstituted ethylenediamines followed by N-acylation. Synthesized compounds have pronounced antiarrhythmic activity and low toxicity.

关键词

styrene oxide, ethylenediamine, diamino alcohols, amino amides, acylation, arrhythmia, biological activity

作者简介

D. Hoang

Moscow Technological University (Institute of Fine Chemical Technology)

编辑信件的主要联系方式.
Email: quanghoang1510@gmail.com
俄罗斯联邦, 86 prosp. Vernadskogo, Moscow, 119571

E. Borisova

Moscow Technological University (Institute of Fine Chemical Technology)

Email: quanghoang1510@gmail.com
俄罗斯联邦, 86 prosp. Vernadskogo, Moscow, 119571

N. Borisova

Moscow Technological University (Institute of Fine Chemical Technology)

Email: quanghoang1510@gmail.com
俄罗斯联邦, 86 prosp. Vernadskogo, Moscow, 119571

N. Asilova

Moscow Technological University (Institute of Fine Chemical Technology)

Email: quanghoang1510@gmail.com
俄罗斯联邦, 86 prosp. Vernadskogo, Moscow, 119571