Three-component green synthesis of 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, a promising antituberculosis drug


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A new simple, technological, and environmentally friendly method for the catalyst-free synthesis in water of a promising antituberculosis drug, 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, was developed. The amount of the solvent in the reaction mixture has a decisive effect on the yield and purity of the target product.

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Yu. Titova

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

编辑信件的主要联系方式.
Email: titova@ios.uran.ru
俄罗斯联邦, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990

O. Fedorova

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: titova@ios.uran.ru
俄罗斯联邦, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990

G. Rusinov

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin

Email: titova@ios.uran.ru
俄罗斯联邦, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990; 19 ul. Mira, Yekaterinburg, 620002

V. Charushin

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin

Email: titova@ios.uran.ru
俄罗斯联邦, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990; 19 ul. Mira, Yekaterinburg, 620002

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