Enviar artigo por via de e-mail Three-component green synthesis of 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, a promising antituberculosis drug
- Autores: Titova Y.A.1, Fedorova O.V.1, Rusinov G.L.1,2, Charushin V.N.1,2
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Afiliações:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B. N. Yeltsin
- Edição: Volume 68, Nº 12 (2019)
- Páginas: 2271-2274
- Seção: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/243558
- DOI: https://doi.org/10.1007/s11172-019-2698-6
- ID: 243558
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Resumo
A new simple, technological, and environmentally friendly method for the catalyst-free synthesis in water of a promising antituberculosis drug, 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, was developed. The amount of the solvent in the reaction mixture has a decisive effect on the yield and purity of the target product.
Sobre autores
Yu. Titova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: titova@ios.uran.ru
Rússia, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990
O. Fedorova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: titova@ios.uran.ru
Rússia, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990
G. Rusinov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: titova@ios.uran.ru
Rússia, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990; 19 ul. Mira, Yekaterinburg, 620002
V. Charushin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: titova@ios.uran.ru
Rússia, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990; 19 ul. Mira, Yekaterinburg, 620002
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