Studying the antagonistic activity of Lactobakterin against Rhodococcus equi in vivo

Abstract

The high antagonistic activity of the probiotic Lactobakterin against Rhodococcus equi in in vitro experiments was the base for studying this probiotic in vivo. In the course of the researches, the intravenous injection of Lactobakterin into white mice was approved and the advisability of this method in the conditions of the experiment was shown. The antagonistic activity of the probiotic Lactobakterin was studied on the mouse model against the virulent strain of Rhodococcus equi. It was stated that the antagonistic activity of the probiotic is 1.25-fold higher under the three-fold intravenous injection into the mice infected intraperitoneally with the strain of Rhodococcus equi than under the 2-fold injection. The intravenous injection of the probiotics is possible upon the condition of their short-term application during the critical periods for the animal.