Antimicrobial Activity of Some New N-Glycosylidene Carbohydrazide Derivatives


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Resumo

New N-glycosyl carbohydrazide derivatives and their annulated C-nucleosides have been synthesized via reaction of N-[4-(hydrazinecarbonyl)phenyl]-8-hydroxy-7-iodoquinoline-5-sulfonamide with different aldoses and characterized by spectroscopic and elemental analyses. Some selected compounds have been screened for activity and 4d showed maximum antimicrobial activity comparable to that of standard drugs.

Sobre autores

N. Khalifa

Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy; Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division

Autor responsável pela correspondência
Email: nagykhalifa@hotmail.com
Arábia Saudita, Riyadh, 11451; Dokki, Cairo, 12622

M. Al-Omar

Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy

Email: nagykhalifa@hotmail.com
Arábia Saudita, Riyadh, 11451

E. Nossier

Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls)

Email: nagykhalifa@hotmail.com
Egito, Cairo

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