Sodium difluoromethanesulfinate—A difluoromethylating agent toward protonated heterocyclic bases
- Authors: Lytkina M.A.1,2, Eliseenkov E.V.2, Boyarskii V.P.2, Petrov A.A.2
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Affiliations:
- St. Petersburg State Institute of Technology
- St. Petersburg State University
- Issue: Vol 53, No 4 (2017)
- Pages: 539-546
- Section: Review
- URL: https://journal-vniispk.ru/1070-4280/article/view/216050
- DOI: https://doi.org/10.1134/S1070428017040066
- ID: 216050
Cite item
Abstract
Free radical difluoromethylation of protonated heteroaromatic bases was accomplished using sodium difluoromethanesulfinate in combination with tert-butyl hydroperoxide in a two-phase system (methylene chloride–water) at room temperature. The difluoromethylation products of methyl pyridine-4-carboxylate, pyridine-4-carbonitrile, and 2-amino-1,3,4-thiadiazole were isolated on a preparative scale.
About the authors
M. A. Lytkina
St. Petersburg State Institute of Technology; St. Petersburg State University
Email: aap1947@yandex.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190005; Universitetskaya nab. 7/9, St. Petersburg, 190005
E. V. Eliseenkov
St. Petersburg State University
Email: aap1947@yandex.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 190005
V. P. Boyarskii
St. Petersburg State University
Email: aap1947@yandex.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 190005
A. A. Petrov
St. Petersburg State University
Author for correspondence.
Email: aap1947@yandex.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 190005
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