Email this article Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines
- Authors: Martinovich Y.A.1, Ramsh S.M.1, Hamoud F.1, Fundamenskii V.S.1, Gurzhii V.V.2, Zakharov V.I.3, Khrabrova E.S.1
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Affiliations:
- St. Petersburg State Institute of Technology
- St. Petersburg State University
- Research Institute of Hygiene, Occupational Pathology, and Human Ecology
- Issue: Vol 54, No 6 (2018)
- Pages: 878-885
- Section: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/218077
- DOI: https://doi.org/10.1134/S107042801806009X
- ID: 218077
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Abstract
Three-component condensation of thiourea with equimolar amounts of formaldehyde and morpholine afforded N-(morpholin-4-ylmethyl) derivative, whereas analogous reaction with 2 equiv of formaldehyde and amine gave symmetrical N,N′-bis(morpholin-4-ylmethyl)thiourea. In the condensation of thiourea with piperidine and formaldehyde, only symmetrical N,N′-bis(piperidin-1-ylmethyl)thiourea was isolated, regardless of the reactant ratio.
About the authors
Yu. A. Martinovich
St. Petersburg State Institute of Technology
Author for correspondence.
Email: jewel1009@ya.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
S. M. Ramsh
St. Petersburg State Institute of Technology
Email: jewel1009@ya.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
F. Hamoud
St. Petersburg State Institute of Technology
Email: jewel1009@ya.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
V. S. Fundamenskii
St. Petersburg State Institute of Technology
Email: jewel1009@ya.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
V. V. Gurzhii
St. Petersburg State University
Email: jewel1009@ya.ru
Russian Federation, Universitetskii pr. 26, St. Petersburg, 198504
V. I. Zakharov
Research Institute of Hygiene, Occupational Pathology, and Human Ecology
Email: jewel1009@ya.ru
Russian Federation, Kapitolovo st. bld. 93, Kuz’molovskii, Leningrad oblast, 188663
E. S. Khrabrova
St. Petersburg State Institute of Technology
Email: jewel1009@ya.ru
Russian Federation, Moskovskii pr. 26, St. Petersburg, 190013
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