Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines

Yu. A. Martinovich; S. M. Ramsh; F. Hamoud; V. S. Fundamenskii; V. V. Gurzhii; V. I. Zakharov; E. S. Khrabrova

doi:10.1134/S107042801806009X

Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines

作者: Martinovich Y.A.¹, Ramsh S.M.¹, Hamoud F.¹, Fundamenskii V.S.¹, Gurzhii V.V.², Zakharov V.I.³, Khrabrova E.S.¹
隶属关系:
1. St. Petersburg State Institute of Technology
2. St. Petersburg State University
3. Research Institute of Hygiene, Occupational Pathology, and Human Ecology
期: 卷 54, 编号 6 (2018)
页面: 878-885
栏目: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/218077
DOI: https://doi.org/10.1134/S107042801806009X
ID: 218077

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Three-component condensation of thiourea with equimolar amounts of formaldehyde and morpholine afforded N-(morpholin-4-ylmethyl) derivative, whereas analogous reaction with 2 equiv of formaldehyde and amine gave symmetrical N,N′-bis(morpholin-4-ylmethyl)thiourea. In the condensation of thiourea with piperidine and formaldehyde, only symmetrical N,N′-bis(piperidin-1-ylmethyl)thiourea was isolated, regardless of the reactant ratio.