Мақаланы E-mail арқылы жіберу A Convenient Synthesis of N2-Alkylated Guanines
- Авторлар: Zhu H.T.1, Qin L.Y.1, Liu T.1, Luo Y.1
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Мекемелер:
- Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
- Шығарылым: Том 55, № 6 (2019)
- Беттер: 874-878
- Бөлім: Review
- URL: https://journal-vniispk.ru/1070-4280/article/view/220788
- DOI: https://doi.org/10.1134/S1070428019060198
- ID: 220788
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Аннотация
An improved three-step synthesis of N2-alkylated guanines has been developed starting from N2-Boc-protected 2-amino-6-chloropurine which was treated with Boc2O, and the resulting doubly N2,9-protected derivative was subjected to N2-alkylation with alkyl halides, followed by hydrolysis. The advantages of this procedure include short reaction steps, simple operations, and good yields.
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Авторлар туралы
H. Zhu
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Email: yluo@chem.ecnu.edu.cn
ҚХР, Shanghai
L. Qin
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Email: yluo@chem.ecnu.edu.cn
ҚХР, Shanghai
T. Liu
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Email: yluo@chem.ecnu.edu.cn
ҚХР, Shanghai
Y. Luo
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Хат алмасуға жауапты Автор.
Email: yluo@chem.ecnu.edu.cn
ҚХР, Shanghai
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