Email this article Assessment of HLA-DRB1 alleles frequencies in patients with pemphigus in Russian population
- Authors: Olisova O.Y.1, Shimanovskiy N.L.2, Dukhanin A.S.2, Teplyuk N.P.1, Lepekhova A.A.1
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Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- The Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 25, No 6 (2022)
- Pages: 33-40
- Section: DERMATOLOGY
- URL: https://journal-vniispk.ru/1560-9588/article/view/132585
- DOI: https://doi.org/10.17816/dv112279
- ID: 132585
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Abstract
BACKGROUND: Pemphigus vulgaris is known to be associated with genetics, immunological and hormonal factors which cause acantholysis resulting in intraepidermal blistering. Moreover, Human class II leukocyte antigen (HLA) alleles are known to be the best-established predisposing factor for its development. Class II HLA alleles vary among racial/ethnic backgrounds.
AIM: we investigated an association between HLA class II DRB1 alleles and pemphigus vulgaris among the Russian population.
MATERIALS AND METHODS: A total of 70 patients with confirmed diagnosis of pemphigus vulgaris were genotyped for HLA class II alleles. HLA class II frequencies were compared with healthy volunteers (n=92). The statistical significance of differences between patients and controls was evaluated using Fisher’s exact test. A single blood sample for HLA typing was obtained from all the subjects. The strength of association between HLA alleles and pemphigus vulgaris was estimated by odds ratio (OR) and 95% confidence intervals (CIs) p <0.01 was considered to be statistically significant. P-values were corrected for multiple comparisons according to the Benjamini–Hochberg method.
RESULTS: We observed that DRB1*4 and DRB1*14 allelic groups were associated with pemphigus vulgaris (41.4% vs 8.7%; OR 2.33 vs 0.34; p=0.000001 and 27.1% vs 6.5%; OR 1.98 vs 0.41; p=0.0004 respectively), while HLA-DRB1*11 and HLA-DRB*15 were negatively associated with pemphigus vulgaris (4.3% vs 21.7%; OR 0.33 vs 1.62; p=0.001 and 5.7% vs 19.6%; OR 0.44 vs 1.5 respectively).
CONCLUSIONS: Our findings suggest, that HLA DRB1*4 and DRB1*14 alleles are genetic markers for pemphigus vulgaris susceptibility, whereas DRB1*11 and HLA-DRB*15 groups appear protective in Russian population.
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##article.viewOnOriginalSite##About the authors
Olga Yu. Olisova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: olisovaolga@mail.ru
ORCID iD: 0000-0003-2482-1754
SPIN-code: 2500-7989
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowNikolai L. Shimanovskiy
The Russian National Research Medical University named after N.I. Pirogov
Email: shiman@rsmu.ru
ORCID iD: 0000-0001-8887-4420
SPIN-code: 5232-8230
MD, Dr. Sci. (Med.), Professor, Corresponding member of the Russian Academy of Sciences
Russian Federation, MoscowAlexander S. Dukhanin
The Russian National Research Medical University named after N.I. Pirogov
Email: das03@rambler.ru
ORCID iD: 0000-0003-2433-7727
SPIN-code: 5028-6000
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowNatalia P. Teplyuk
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: teplyukn@gmail.com
ORCID iD: 0000-0002-5800-4800
SPIN-code: 8013-3256
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowAnfisa A. Lepekhova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: anfisa.lepehova@yandex.ru
ORCID iD: 0000-0002-4365-3090
SPIN-code: 3261-3520
MD, Cand. Sci. (Med.), Associate Professor
Russian Federation, MoscowReferences
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