Identification of tinctures by the polarimetric method
- Authors: Syroeshkin A.V1, Ogotoeva D.D1, Galkina D.A1, Dzhavakhyan M.A2, Elizarova T.E3, Uspenskaya E.V1, Pleteneva T.V1
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Affiliations:
- Peoples' Friendship University of Russia
- All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
- «KoAl Farmanaliz» LLC
- Issue: Vol 25, No 9 (2022)
- Pages: 3-9
- Section: Articles
- URL: https://journal-vniispk.ru/1560-9596/article/view/143456
- DOI: https://doi.org/10.29296/25877313-2022-09-01
- ID: 143456
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Abstract
Relevance. The ambiguity of the observed therapeutic effects of tinctures and the absence of pharmacopoeial articles require the development of new approaches to their quality control. In this work, for the first time, the polarimetry method and the dynamic light scattering method were used to identify tinctures with sedative and cardiotonic effects. The purpose. To develop the methods of polarimetry and dynamic light scattering for quality control of valerian, motherwort and hawthorn tinctures Material and methods. Objects of research: tinctures of rare series from different manufacturers. Methods: polarimetry (POL-1/2, Atago, Japan); dynamic light scattering method - DLS (Zetasizer Nano ZS, Malvern, UK). Results. Polarimetric method established that tinctures are optically active environment. This made it possible to develop a method for identifying tinctures with sedative and cardiotonic effects, which is based on measuring the optical rotation angle of 95% ethanol dilutions of different multiplicities. When diluting valerian tincture in a ratio of 1:40, the angle of optical rotation is in the range of -0.10°
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##article.viewOnOriginalSite##About the authors
A. V Syroeshkin
Peoples' Friendship University of Russia
Email: livmatter@mail.ru
Dr.Sc. (Biol.), Professor, Head of Department of Pharmaceutical and Toxicological Chemistry, Medical Institute
D. D Ogotoeva
Peoples' Friendship University of Russia
Email: livmatter@mail.ru
Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute
D. A Galkina
Peoples' Friendship University of Russia
Email: livmatter@mail.ru
Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute
M. A Dzhavakhyan
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: livmatter@mail.ru
Dr.Sc. (Pharm.), Chief Research Scientist
T. E Elizarova
«KoAl Farmanaliz» LLC
Email: livmatter@mail.ru
Ph.D. (Pharm.), General Manager
E. V Uspenskaya
Peoples' Friendship University of Russia
Email: livmatter@mail.ru
Dr.Sc. (Pharm.), Professor, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute
T. V Pleteneva
Peoples' Friendship University of Russia
Author for correspondence.
Email: livmatter@mail.ru
Dr.Sc. (Chem.), Professor, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute
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