Email this article N-acyl dopamines induce cell death in PC12 cell line via induction of nitric oxide generation and oxidative stress
- Authors: Ashba A.M.1, Akimov M.G.1, Gretskaya N.M.1, Bezuglov V.V.1
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Issue: Vol 467, No 1 (2016)
- Pages: 81-84
- Section: Biochemistry, Biophysics and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211013
- DOI: https://doi.org/10.1134/S1607672916020010
- ID: 211013
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Abstract
It was shown that dopamine amides of arachidonic, oleic, and docosahexaenoic acids exhibit toxicity with respect to PC12 pheochromocytoma cell line. The mechanism of realization of the cytotoxic effect of acyl dopamines is the induction of oxidative stress. This event is preceded by triggering the synthesis of nitric oxide.
About the authors
A. M. Ashba
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: akimovmike@yandex.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
M. G. Akimov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: akimovmike@yandex.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
N. M. Gretskaya
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: akimovmike@yandex.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
V. V. Bezuglov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: akimovmike@yandex.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
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