The inhibitors of Arp2/3 complex and WASP proteins modulate the effect of glutoxim on Na+ transport in frog skin


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Abstract

Using voltage-clamp technique, the involvement of WASP proteins and Arp2/3 complex in the effect of immunomodulator drug glutoxim on Na+ transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with the N-WASP inhibitor wiskostatin or the Arp2/3 complex inhibitor CK-0944666 significantly decreases the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of actin filament polymerization and branching in the glutoxim effect on Na+ transport in frog skin.

About the authors

Z. I. Krutetskaya

St. Petersburg State University

Author for correspondence.
Email: zk@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

A. V. Melnitskaya

St. Petersburg State University

Email: zk@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

V. G. Antonov

St. Petersburg State University

Email: zk@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

A. D. Nozdrachev

St. Petersburg State University

Email: zk@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

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