The inhibitors of Arp2/3 complex and WASP proteins modulate the effect of glutoxim on Na+ transport in frog skin
- Authors: Krutetskaya Z.I.1, Melnitskaya A.V.1, Antonov V.G.1, Nozdrachev A.D.1
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Affiliations:
- St. Petersburg State University
- Issue: Vol 467, No 1 (2016)
- Pages: 102-104
- Section: Biochemistry, Biophysics and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211031
- DOI: https://doi.org/10.1134/S1607672916020071
- ID: 211031
Cite item
Abstract
Using voltage-clamp technique, the involvement of WASP proteins and Arp2/3 complex in the effect of immunomodulator drug glutoxim on Na+ transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with the N-WASP inhibitor wiskostatin or the Arp2/3 complex inhibitor CK-0944666 significantly decreases the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of actin filament polymerization and branching in the glutoxim effect on Na+ transport in frog skin.
Keywords
About the authors
Z. I. Krutetskaya
St. Petersburg State University
Author for correspondence.
Email: zk@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
A. V. Melnitskaya
St. Petersburg State University
Email: zk@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
V. G. Antonov
St. Petersburg State University
Email: zk@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
A. D. Nozdrachev
St. Petersburg State University
Email: zk@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
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