Email this article Peroxiredoxin 6 is a natural radioprotector
- Authors: Sharapov M.G.1, Gudkov S.V.2,3,4,5, Gordeeva A.E.1,4, Karp O.E.2, Ivanov V.E.2, Shelkovskaya O.V.2,4, Bruskov V.I.2,4, Novoselov V.I.1,4, Fesenko E.E.1
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Affiliations:
- Institute of Cell Biophysics
- Institute of Theoretical and Experimental Biophysics
- Prokhorov Institute of General Physics
- Pushchino State Natural Science Institute
- Lobachevskii Nizhny Novgorod State University
- Issue: Vol 467, No 1 (2016)
- Pages: 110-112
- Section: Biochemistry, Biophysics and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211039
- DOI: https://doi.org/10.1134/S1607672916020095
- ID: 211039
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Abstract
After injection of 20 mg/kg peroxiredoxin 6 to male Kv:SHK mice 15 min before X-ray irradiation in the range of lethal doses (7–10 Gy), the mice remained alive for 30 days, whereas the mortality of the control animals was 100%. In the irradiated animals, peroxiredoxin 6 decreased the severity of radiation-induced leucopenia, granulocytopenia, and thrombocytopenia, increased the number of blood corpuscles, and prevented the mass death of epithelial cells and the destruction of the small intestine. Thus, peroxiredoxin 6 can be regarded as a prophylactic radioprotective agent.
About the authors
M. G. Sharapov
Institute of Cell Biophysics
Author for correspondence.
Email: sharapov.mars@gmail.com
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290
S. V. Gudkov
Institute of Theoretical and Experimental Biophysics; Prokhorov Institute of General Physics; Pushchino State Natural Science Institute; Lobachevskii Nizhny Novgorod State University
Email: sharapov.mars@gmail.com
Russian Federation, pr. Nauki 3, Pushchino, Moscow oblast, 142290; ul. Vavilova 38, Moscow, 119991; Pushchino, Moscow oblast, 142290; Nizhny Novgorod, 603600
A. E. Gordeeva
Institute of Cell Biophysics; Pushchino State Natural Science Institute
Email: sharapov.mars@gmail.com
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290; Pushchino, Moscow oblast, 142290
O. E. Karp
Institute of Theoretical and Experimental Biophysics
Email: sharapov.mars@gmail.com
Russian Federation, pr. Nauki 3, Pushchino, Moscow oblast, 142290
V. E. Ivanov
Institute of Theoretical and Experimental Biophysics
Email: sharapov.mars@gmail.com
Russian Federation, pr. Nauki 3, Pushchino, Moscow oblast, 142290
O. V. Shelkovskaya
Institute of Theoretical and Experimental Biophysics; Pushchino State Natural Science Institute
Email: sharapov.mars@gmail.com
Russian Federation, pr. Nauki 3, Pushchino, Moscow oblast, 142290; Pushchino, Moscow oblast, 142290
V. I. Bruskov
Institute of Theoretical and Experimental Biophysics; Pushchino State Natural Science Institute
Email: sharapov.mars@gmail.com
Russian Federation, pr. Nauki 3, Pushchino, Moscow oblast, 142290; Pushchino, Moscow oblast, 142290
V. I. Novoselov
Institute of Cell Biophysics; Pushchino State Natural Science Institute
Email: sharapov.mars@gmail.com
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290; Pushchino, Moscow oblast, 142290
E. E. Fesenko
Institute of Cell Biophysics
Email: sharapov.mars@gmail.com
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290
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