Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells


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Abstract

The effect of the transcription factor Oct-1 (POU2F1) on the expression of the tumor cell marker metastasin (Mts1/S100A4) was studied. Comparative analysis of various tumor lines showed no clear correlation between the expression level of Mts1/S100A4 and the content of Oct-1. However, at stable transfection of tumor cells with Oct-1A, Oct-1L, and Oct-1X isoforms we detected an elevated level of Oct-1, which stimulated Mts1/S100A4 secretion. These findings extend our understanding of the molecular mechanisms of the tumorigenic effect of Oct-1.

About the authors

T. N. Portseva

Engelhardt Institute of Molecular Biology

Author for correspondence.
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991

A. V. Brechalov

Engelhardt Institute of Molecular Biology

Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991

E. A. Dukhanina

Engelhardt Institute of Molecular Biology

Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991

A. G. Stepchenko

Engelhardt Institute of Molecular Biology

Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991

E. V. Pankratova

Engelhardt Institute of Molecular Biology

Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991

S. G. Georgieva

Engelhardt Institute of Molecular Biology

Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991

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