Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells
- Authors: Portseva T.N.1, Brechalov A.V.1, Dukhanina E.A.1, Stepchenko A.G.1, Pankratova E.V.1, Georgieva S.G.1
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Affiliations:
- Engelhardt Institute of Molecular Biology
- Issue: Vol 467, No 1 (2016)
- Pages: 121-123
- Section: Biochemistry, Biophysics and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/211055
- DOI: https://doi.org/10.1134/S1607672916020125
- ID: 211055
Cite item
Abstract
The effect of the transcription factor Oct-1 (POU2F1) on the expression of the tumor cell marker metastasin (Mts1/S100A4) was studied. Comparative analysis of various tumor lines showed no clear correlation between the expression level of Mts1/S100A4 and the content of Oct-1. However, at stable transfection of tumor cells with Oct-1A, Oct-1L, and Oct-1X isoforms we detected an elevated level of Oct-1, which stimulated Mts1/S100A4 secretion. These findings extend our understanding of the molecular mechanisms of the tumorigenic effect of Oct-1.
About the authors
T. N. Portseva
Engelhardt Institute of Molecular Biology
Author for correspondence.
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
A. V. Brechalov
Engelhardt Institute of Molecular Biology
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
E. A. Dukhanina
Engelhardt Institute of Molecular Biology
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
A. G. Stepchenko
Engelhardt Institute of Molecular Biology
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
E. V. Pankratova
Engelhardt Institute of Molecular Biology
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
S. G. Georgieva
Engelhardt Institute of Molecular Biology
Email: tanjnij86@mail.ru
Russian Federation, ul. Vavilova 32, Moscow, 119991
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