Pleiotropic effect of thyroid hormones on gene expression in fish as exemplified from the blue bream Ballerus ballerus (Cyprinidae): Results of transcriptomic analysis


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

A pronounced pleiotropic effect of thyroid hormones on the regulation of gene expression in fish in postembryogenesis was demonstrated for the first time using larvae and juveniles of the blue bream Ballerus ballerus as an example. Genome-wide transcriptome sequencing (RNA-seq) identified 1212 differentially expressed genes in the brain and liver of fish kept in triiodothyronine solution (0.25 ng/mL). Our data show that the regulation of gene expression by thyroid hormones is widespread in nature: it involves not only the structural genes but also the regulatory genes. A significant number of genes under the control of thyroid hormones are involved in the determination of morphological traits.

About the authors

S. M. Rastorguev

National Research Center Kurchatov Institute

Author for correspondence.
Email: rastorgueff@gmail.com
Russian Federation, pl. Akademika Kurchatova 1, Moscow, 123182

A. V. Nedoluzhko

National Research Center Kurchatov Institute

Email: rastorgueff@gmail.com
Russian Federation, pl. Akademika Kurchatova 1, Moscow, 123182

M. A. Levina

Institute of Bioengineering, Federal Research Center “Fundamentals of Biotechnology,”

Email: rastorgueff@gmail.com
Russian Federation, Leninskii pr. 33-2, Moscow, 119071

E. B. Prokhorchuk

Institute of Bioengineering, Federal Research Center “Fundamentals of Biotechnology,”

Email: rastorgueff@gmail.com
Russian Federation, Leninskii pr. 33-2, Moscow, 119071

K. G. Skryabin

National Research Center Kurchatov Institute; Institute of Bioengineering, Federal Research Center “Fundamentals of Biotechnology,”

Email: rastorgueff@gmail.com
Russian Federation, pl. Akademika Kurchatova 1, Moscow, 123182; Leninskii pr. 33-2, Moscow, 119071

B. A. Levin

Institute of Bioengineering, Federal Research Center “Fundamentals of Biotechnology,”

Email: rastorgueff@gmail.com
Russian Federation, Leninskii pr. 33-2, Moscow, 119071

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2016 Pleiades Publishing, Ltd.