MNT Optimization for Intracellular Delivery of Antibody Fragments

A. V. Ulasov; Y. V. Khramtsov; T. N. Lupanova; A. D. Tsvetkova; A. A. Rosenkranz; T. A. Slastnikova; G. P. Georgiev; A. S. Sobolev

doi:10.1134/S1607672918020023

MNT Optimization for Intracellular Delivery of Antibody Fragments

Authors: Ulasov A.V.¹, Khramtsov Y.V.¹, Lupanova T.N.¹, Tsvetkova A.D.¹^,2, Rosenkranz A.A.¹^,2, Slastnikova T.A.¹, Georgiev G.P.¹, Sobolev A.S.¹^,2
Affiliations:
1. Institute of Gene Biology
2. Faculty of Biology
Issue: Vol 479, No 1 (2018)
Pages: 62-65
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/212136
DOI: https://doi.org/10.1134/S1607672918020023
ID: 212136

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

We studied the possibility of optimizing modular nanotransporters (MNTs) for the intracellular delivery of antibody fragments into the nuclei of cells of a specified type. Basic MNT with a reduced size retaining the desired functions was obtained, and the principal possibility of obtaining an MNT carrying an antibody fragment by microbiological synthesis was shown.