Estrogen Receptors alpha and beta in Ovarian Cancer: Expression Level and Prognosis
- Authors: Bogush T.A.1, Basharina A.A.1,2, Bogush E.A.1, Ryabinina O.M.1, Tjulandina A.S.1, Tjulandin S.A.1
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Affiliations:
- Blokhin Russian Cancer Research Center
- Faculty of Fundamental Medicine
- Issue: Vol 482, No 1 (2018)
- Pages: 249-251
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212437
- DOI: https://doi.org/10.1134/S1607672918050058
- ID: 212437
Cite item
Abstract
The quantitative immunofluorescence assay of serous ovarian cancer tissue for the expression of estrogen receptors (ERα and ERβ) revealed a higher expression level of ERβ in comparison with ERα in all surgical tumor samples investigated. Significant differences in the expression level of the markers were detected “from tumor to tumor.” A high expression level of both ERα (≥ 25%) and ERβ (≥ 44%) in the tumor predicts a significantly longer progression-free survival time (p < 0.01) in the patients after the first line of platinum and taxane-based adjuvant chemotherapy.
About the authors
T. A. Bogush
Blokhin Russian Cancer Research Center
Author for correspondence.
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478
A. A. Basharina
Blokhin Russian Cancer Research Center; Faculty of Fundamental Medicine
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478; Moscow, 119192
E. A. Bogush
Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478
O. M. Ryabinina
Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478
A. S. Tjulandina
Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478
S. A. Tjulandin
Blokhin Russian Cancer Research Center
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478
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