Estrogen Receptors alpha and beta in Ovarian Cancer: Expression Level and Prognosis


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Abstract

The quantitative immunofluorescence assay of serous ovarian cancer tissue for the expression of estrogen receptors (ERα and ERβ) revealed a higher expression level of ERβ in comparison with ERα in all surgical tumor samples investigated. Significant differences in the expression level of the markers were detected “from tumor to tumor.” A high expression level of both ERα (≥ 25%) and ERβ (≥ 44%) in the tumor predicts a significantly longer progression-free survival time (p < 0.01) in the patients after the first line of platinum and taxane-based adjuvant chemotherapy.

About the authors

T. A. Bogush

Blokhin Russian Cancer Research Center

Author for correspondence.
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478

A. A. Basharina

Blokhin Russian Cancer Research Center; Faculty of Fundamental Medicine

Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478; Moscow, 119192

E. A. Bogush

Blokhin Russian Cancer Research Center

Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478

O. M. Ryabinina

Blokhin Russian Cancer Research Center

Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478

A. S. Tjulandina

Blokhin Russian Cancer Research Center

Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478

S. A. Tjulandin

Blokhin Russian Cancer Research Center

Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478

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