Sigma-1 Receptor Antagonists Haloperidol and Chlorpromazine Modulate the Effect of Glutoxim on Na+ Transport in Frog Skin


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Abstract

Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+ transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine attenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possible involvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.

About the authors

Z. I. Krutetskaya

St. Petersburg State University

Author for correspondence.
Email: z.krutetskaya@spbu.ru
Russian Federation, St. Petersburg, 199034

A. V. Melnitskaya

St. Petersburg State University

Email: z.krutetskaya@spbu.ru
Russian Federation, St. Petersburg, 199034

V. G. Antonov

St. Petersburg State University

Email: z.krutetskaya@spbu.ru
Russian Federation, St. Petersburg, 199034

A. D. Nozdrachev

St. Petersburg State University

Email: z.krutetskaya@spbu.ru
Russian Federation, St. Petersburg, 199034

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