Sigma-1 Receptor Antagonists Haloperidol and Chlorpromazine Modulate the Effect of Glutoxim on Na+ Transport in Frog Skin
- Authors: Krutetskaya Z.I.1, Melnitskaya A.V.1, Antonov V.G.1, Nozdrachev A.D.1
-
Affiliations:
- St. Petersburg State University
- Issue: Vol 484, No 1 (2019)
- Pages: 63-65
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212769
- DOI: https://doi.org/10.1134/S1607672919010186
- ID: 212769
Cite item
Abstract
Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+ transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine attenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possible involvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.
About the authors
Z. I. Krutetskaya
St. Petersburg State University
Author for correspondence.
Email: z.krutetskaya@spbu.ru
Russian Federation, St. Petersburg,
199034
A. V. Melnitskaya
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Russian Federation, St. Petersburg,
199034
V. G. Antonov
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Russian Federation, St. Petersburg,
199034
A. D. Nozdrachev
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Russian Federation, St. Petersburg,
199034
Supplementary files
