电邮这篇文章 Effectiveness of Enzymatic Necrolysis in Patients with Burns
- 作者: Alekseyev A.A.1,2,3, Bobrovnikov A.E.1,2, Malyutina N.B.1,2,3, Bogdanov V.V.2, Chilikin N.M.2, Markarov A.E.3
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隶属关系:
- Russian Medical Academy of Continuous Professional Education
- A.V. Vishnevsky National Medical Research Center of Surgery
- City Clinical Hospital named after F.I. Inozemtsev of the Moscow Health Department
- 期: 卷 17, 编号 4 (2024)
- 页面: 183-191
- 栏目: Experience
- URL: https://journal-vniispk.ru/2070-478X/article/view/273801
- DOI: https://doi.org/10.18499/2070-478X-2024-17-4-183-191
- ID: 273801
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Rationale. Currently, there has been developed a technique for managing enzymatic necrolysis of II-III degree burn wounds using the two-component drug NexoBrid; this treatment option is possible to apply only in the early terms, up to 72 hours, after injury. There are no indications for the use of the technology in later terms after the injury.
The aim of research was to study the potential and effectiveness of enzymatic necrolysis when using the drug NexoBrid in patients with burns of II-III degree at various stages after injury (before and after 72 hours).
Methods. The study included 23 patients. In 15 cases, enzymatic necrolysis with Nexobrid was carried out in first 72 hours after injury; in 8 cases, in 5-9 days after injury.
Results. In both groups, comparable results were obtained regarding the effectiveness of enzymatic necrolysis. The use of enzymatic necrolysis at the late stages (7 days) after injury was effective in the presence of moist necrotic tissue in the wounds, which allowed simultaneously, in the shortest possible time, cleaning burn wounds with uncomplete dermal necrosis (borderline burns of II degree and “mosaic” burns II-III degree) from necrosis, transforming wound process to second stage, creating conditions for regeneration of borderline and “mosaic” burns from the remaining skin derivatives with underlying use of dressings, thus creating a moist wound environment, and in the case of deep burns, reducing the time of their preparation and the area of autodermoplasty.
Conclusion. The use of enzymatic necrolysis with the drug NexoBrid in patients with burns of II-III degree is effective up to 7 days after injury in the presence of a moist scab in the wounds.
作者简介
Andrey Alekseyev
Russian Medical Academy of Continuous Professional Education; A.V. Vishnevsky National Medical Research Center of Surgery; City Clinical Hospital named after F.I. Inozemtsev of the Moscow Health Department
编辑信件的主要联系方式.
Email: alexseev@ixv.ru
ORCID iD: 0000-0001-6675-4794
SPIN 代码: 4803-3939
Scopus 作者 ID: 720289106
M.D., Professor, Deputy Director, Head of the Burn, Head of the Department of Thermal Lesions, Wounds and Wound Infection
俄罗斯联邦, Moscow; Moscow; MoscowAlexander Bobrovnikov
Russian Medical Academy of Continuous Professional Education; A.V. Vishnevsky National Medical Research Center of Surgery
Email: doctorbobr@mail.ru
ORCID iD: 0000-0003-0926-6115
SPIN 代码: 4203-1718
Scopus 作者 ID: 6602689492
M.D., Associate Professor, Head of the Burn Department, Professor of the Department of Thermal Lesions, Wounds and Wound Infection
俄罗斯联邦, Moscow; MoscowNatalia Malyutina
Russian Medical Academy of Continuous Professional Education; A.V. Vishnevsky National Medical Research Center of Surgery; City Clinical Hospital named after F.I. Inozemtsev of the Moscow Health Department
Email: malutinanb@yandex.ru
ORCID iD: 0000-0001-8013-1913
SPIN 代码: 6092-7986
Ph.D., specialist of the Organizational and Methodological Department, Associate Professor of the Department of Thermal Lesions
俄罗斯联邦, Moscow; Moscow; MoscowVitaly Bogdanov
A.V. Vishnevsky National Medical Research Center of Surgery
Email: vbogdanov@inbox.ru
ORCID iD: 0000-0001-8499-9373
surgeon of the burn department
俄罗斯联邦, MoscowNikolai Chilikin
A.V. Vishnevsky National Medical Research Center of Surgery
Email: zero-nbk@yandex.ru
ORCID iD: 0000-0003-0096-5681
SPIN 代码: 7868-4353
surgeon of the burn Department
俄罗斯联邦, MoscowArnold Markarov
City Clinical Hospital named after F.I. Inozemtsev of the Moscow Health Department
Email: gkb36@zdrav.mos.ru
ORCID iD: 0000-0002-0392-8280
SPIN 代码: 8919-9645
surgeon of the burn Department
俄罗斯联邦, Moscow参考
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