Efficacy and safety of the Actitropil in the treatment of reactive asthenia in young patients
- Authors: Vizilo T.L.1
-
Affiliations:
- Kemerovo State Medical University
- Issue: Vol 30, No 9/10 (2023)
- Pages: 159-166
- Section: Neurology
- URL: https://journal-vniispk.ru/2073-4034/article/view/275594
- DOI: https://doi.org/10.18565/pharmateca.2023.9-10.159-166
- ID: 275594
Cite item
Open Access
Access granted
Subscription Access
Abstract
Background. Asthenic syndrome (AS) occurs in the practice of doctors of all specialties, and its frequency and prevalence tend to steadily increase, especially among young and middle-aged population groups. Therapy for AS should be carried out in accordance with the etiological factors and the main clinical manifestations; however, the correction of asthenic manifestations continues to be a complex medical problem.
Objective. Evaluation of the clinical effectiveness and safety of using the phenylpiracetam (Actitropil) in patients with AS.
Methods. An open, observational, prospective, non-comparative, non-randomized study included 50 patients aged 18 to 30 years (mean age 24.7±5.4 years), with clinical manifestations of reactive asthenia lasting from 3 to 6 months. Patients received Actitropil at a dose of 200 mg/day. The duration of therapy was 30 days, the total follow-up period was 60 days.
Results. The results of the study showed the high effectiveness and safety of Actitropil in the treatment of AS. During therapy, by the end of the 1st month of treatment, the severity of AS significantly decreased according to the MFI-20 (from 76.0±5.5 to 58.0±6.2 points; P<0.05) and WAM scales, and psychoemotional state has improved (total HADS score decreased from 16.1±4.7 to 12.2±3.9; P<0.05) as well as and sleep (dynamics on the Spiegel scale from 16.9±2.1 to 20.9 ±2.1; P<0.05). The drug was well tolerated and had no side effects.
Conclusion. Actitropil at a dose of 200 mg/day for a month can be recommended for the treatment of AS, in particular for the correction of clinical manifestations of reactive asthenia in young people as monotherapy.
Full Text
##article.viewOnOriginalSite##About the authors
T. L. Vizilo
Kemerovo State Medical University
Author for correspondence.
Email: vizilo@yandex.ru
ORCID iD: 0000-0001-5908-311X
Dr. Sci. (Med.), Professor
Russian Federation, KemerovoReferences
- Воробьева О.В. Многогранность феномена астении. Русский медицинский журнал. 2012;20(5):248–51. [Vorobyova O.V. The versatility of the phenomenon of asthenia. Russkiy meditsinskiy zhurnal. 2012;20(5):248–51. (In Russ.)].
- Лебедев М.А., Палатов С.Ю., Ковров Г.В. и др. Астения – симптом, синдром, болезнь. Эффективная фармакотерапия. Неврология и психиатрия. 2014;1:30–8. [Lebedev M.A., Palatov S.Yu., Kovrov G.V. et al. Asthenia – symptom, syndrome, disease. Effektivnaya farmakoterapiya. 2014;1:30–8. (In Russ.)].
- Чутко Л.С., Сурушкина С.Ю. Астенические расстройства. История и современность. Журнал неврологии и психиатрии им. С.С. Корсакова. 2020;120(6):131–36. [Chutko L.S., Surushkina S.Yu. Asthenic disorders. History and modernity. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2020;120(6):131–6. (In Russ.)]. doi: 10.17116/jnevro2020120061131.
- Путилина М.В. Астенические расстройства как проявление синдрома хронической усталости. Журнал неврологии и психиатрии им. С.С. Корсакова. 2021;121(8):125–30. [Putilina M.V. Putilina M.V. Asthenic disorders as a manifestation of chronic fatigue syndrome. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2021;121(8):125–30. (In Russ.)]. doi: 10.17116/jnevro2021121081125.
- Воробьева Ю.Д., Данилов А.Б. Синдром хронической усталости: современные аспекты диагностики и лечения. Журнал неврологии и психиатрии им. С.С. Корсакова. 2021;121(4):113 – 20. [Vorobyova Yu.D., Danilov A.B. Chronic fatigue syndrome: modern aspects of diagnosis and treatment. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2021;121(4):113–20. (In Russ.)]. doi: 10.17116/jnevro20211214021131.
- Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine. Washington (DC): National Academies Press (US), 2015. doi: 10.17226/19012.
- Иванова А.В., Гоголева В.С. Влияние гаджетов на здоровье подростков. Юный ученый. 2020;32(2): 24–6. [Ivanova A.V., Gogoleva V.S. The influence of gadgets on the health of adolescents. Yunyy uchenyy. 2020;32(2): 24–6. (In Russ.)].
- Захарова И.Н., Творогова Т.М., Пшеничникова И.И. Астенический синдром у школьников: от риска развития до диагностики и лечения. Педиатрия. Consilium Medicum. 2021;1:76–83. doi: 10.26442/26586630.2021.1.200713. [Zakharova I.N., Tvorogova T.M., Pshenichnikova I.I. Asthenic syndrome in schoolchildren: from the risk of development to diagnosis and treatment. Pediatriya. Consilium Medicum. 2021;1:76–83. (In Russ.)].
- Панков Д.Д., Панкова Т.Б., Ковригина Е.С., Ключникова И.В. Диагностика астенического синдрома у школьников и методы его коррекции. Русский медицинский журнал. Медицинское обозрение. 2019;3:45–50. [Pankov D.D., Pankova T.B., Kovrigina E.S., Klyuchnikova I.V. Diagnosis of asthenic syndrome in schoolchildren and methods of its correction. Russkiy meditsinskiy zhurnal. Meditsinskoye obozreniye. 2019;3:45–50. (In Russ.)].
- Дюкова Г.М. Астенический синдром: проблемы диагностики и терапии. Эффективная фармакотерапия. 2012;1:40–5. [Dyukova G.M. Dyukova G.M. Asthenic syndrome: problems of diagnosis and therapy. 2012;1:40–5. (In Russ.)].
- Федин А.И., Соловьева Э.Ю., Миронова О.П., Федотова А.В. Лечение астенического синдрома у больных хронической ишемией головного мозга (результаты неинтервенционной наблюдательной программы ТРИУМФ). Журнал неврологии и психиатрии им. С.С. Корсакова. 2014;114(12):104–11. [Fedin A.I., Solovyova E.Yu., Mironova O.P., Fedotova A.V. Treatment of asthenic syndrome in patients with chronic cerebral ischemia (results of the non-interventional observational program TRIUMPH). Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2014;114(12):104–11. (In Russ.)].
- Шишкова В.Н., Мартынов А.И., Драницына Б.Г. и др. Вопросы коррекции астении в условиях реальной клинической практики у пациентов терапевтического профиля. Терапия. 2022;8(7):129–39. [Shishkova V.N., Martynov A.I., Dranitsyna B.G., et al. Issues of correction of asthenia in real clinical practice in therapeutic patients. Therapy=Terapiya. 2022;8(7):129–39. (In Russ.)]. doi: 10.18565/therapy. 2022.7.
- Инструкция по применению препарата Актитропил. URL: https://grls.rosminzdrav.ru.
- Smets E.M., Garssen B., Bonke B., De Haes J.C. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosomat Res. 1995;39(3):315–25.
- Доскин В.А., Лаврентьева Н.А., Мирошников М.П., Шарай В.Б. Тест дифференцированной самооценки функционального состояния. Вопросы психологии. 1973;19(6):141–45. [Doskin V.A., Lavrent’yeva N.A., Miroshnikov M.P., Sharay V.B. Test of differentiated self-assessment of functional state. Voprosy psikhologii. 1973;19(6):141–45. (In Russ.)].
- Карлинская И.М., Леонова А.Б. Тест Самочувствие, активность, настроение (САН). Практикум по психодиагностике. Конкретные психодиагностические методики. М., 1989. [Karlinskaya I.M., Leonova A.B. Test Well-being, activity, mood (SAN). Workshop on psychodiagnostics. Specific psychodiagnostic techniques. M., 1989. (In Russ.)].
- Zigmond A.S., Snaith R.P. The hospital anxiety and depression scale. Acta Psych Scandinav. 1983;67(6):361–70.
- Полуэктов М.Г. Инсомнии. В кн.: Сомнология и медицина сна: Национальное руководство. М., 2016. С. 298–318. [Poluektov M.G. Insomnia. In the book: Somnology and sleep medicine: National guidelines. M., 2016. p. 298–318. (In Russ.)].
- Busner J., Targum S.D. The clinical global impressions scale: applying a research tool in clinical practice. Psych (Edgmont). 2007; 4(7):28–37.
Supplementary files
