Nasopharyngeal sarcoidosis: a clinical case

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Abstract

Sarcoidosis is a chronic multisystem inflammatory disease characterized by non-caseous granulomas, most commonly in the lungs and intrathoracic lymph nodes. The nasopharyngeal disease is a rare localization of sarcoidosis. Clinical presentations include difficulty in nasal breathing, rhinophonia, and postnasal syndrome. Nasopharyngeal endoscopy, computed tomography, and magnetic resonance imaging are the main diagnostic methods for detecting lesions in this area. The histological examination provides the diagnosis verification. Considering the frequent secondary spread of sarcoidosis, all patients should consult a rheumatologist to select adequate systemic therapy. We provide a clinical case illustrating the management of a patient with nasopharyngeal sarcoidosis.

About the authors

Kseniia I. Sapova

Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech

Author for correspondence.
Email: ksenia_sapova@mail.ru
ORCID iD: 0000-0002-8227-1423

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Stanislav S. Gaydukov

Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech

Email: gsstas@mail.ru
ORCID iD: 0000-0001-7811-9835

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Aleksey V. Voronov

Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech

Email: voronovdoc@mail.ru
ORCID iD: 0000-0003-4030-8571

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Arkadiy N. Naumenko

Sokolov North-Western District Scientific and Clinical Center

Email: naumenko_rhinosurgery@gmail.com
ORCID iD: 0000-0002-7180-4829

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Irina I. Sarkisyan

Saint Petersburg State Pediatric Medical University

Email: dr.sarkisyan.ir@mail.ru
ORCID iD: 0000-0001-8200-714X

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

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2. Figure 1. Endoscopy of a patient diagnosed with nasopharyngeal sarcoidosis.

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3. Figure 2. Computed tomography findings of the paranasal sinuses in a patient diagnosed with nasopharyngeal sarcoidosis. The arrows indicate the pathological process.

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4. Figure 3. Results of magnetic resonance imaging of the paranasal sinuses in a patient diagnosed with nasopharyngeal sarcoidosis. The arrows indicate the pathological process.

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5. Figure 4. Morphological picture of sarcoidosis - nasopharyngeal tissue with numerous diffuse noncaseating epithelioid granulomas consisting of epithelioid cells (a–d) with sparse Langhans giant cells (highlighted by arrows in Fig. b).

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