The relationship of JAK/STAT and MAPK/SAPK signaling pathways, NF-kB and content in the mononuclear cells of whole blood thioredoxins in the post-clinical stage of community-acquired pneumonia

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The study discusses the relationship between the content of mononuclear cells in peripheral blood (MNC) of the MAPK/SAPK and JAK/STAT-signaling pathways, nuclear transcription factor NF-kB, and thioredoxin reductase. The content and level of phosphorylation of signal transducers and transcription activators STAT3, STAT5A, STAT6, nuclear transcription factor NF-kB (IkBa), stress-activated protein kinases JNK, ERK, mitogen-activated protein kinase p38, the level of nuclear transcription factor NF-kB subunit p65 were determined by enzyme immunoassay in MNCs. The results of the study indicate that the stage of reconvalescence of VP is characterized by a deficiency of antioxidant protection, manifested by a decrease in the concentration of antioxidants by 6.7% (p=0.051), despite the existing increase in the level of MNC thioredoxin reductase by 16.3% (p=0.028). This fact indicates the need for correction of the state of AOSIS in patients who have undergone EAP. The analysis revealed a significant relationship between the level of TR and STAT5A, as well as the content of P65 and STAT6, characterized by a positive correlation with these factors.

About the authors

S. S Bondar

Tula State University

аспирант каф. внутренних болезней Медицинского института 300012, Russian Federation, Tula, pr. Lenina, d. 92

I. V Terekhov

Tula State University

Email: trft@mail.ru
канд. мед. наук, доц. каф. общей патологии Медицинского института 300012, Russian Federation, Tula, pr. Lenina, d. 92

V. S Nikiforov

I.I.Mechnikov North-West State Medical University of the Ministry of Health of the Russian Federation

Email: viktor.nikiforov@szgmu.ru
д-р мед. наук, проф., проф. каф. функциональной диагностики 191015, Russian Federation, Saint Petersburg, ul. Kirochnaia, d. 41

V. K Parfenyuk

V.I.Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federation

д-р мед. наук, проф., проф. каф. факультетской терапии лечебного фак-та 410012, Russian Federation, Saratov, ul. Bol'shaia Kazach'ia, d. 112

N. V Bondar

I.S.Turgenev Orel State University

Email: bon.nelli@yandex.ru
канд. биол. наук, доц., проф. каф. безопасности жизнедеятельности в техносфере и защиты человека в чрезвычайных ситуациях 302026, Russian Federation, Orel, ul. Komsomolskaya, d. 95

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