POSSIBLE AUTOIMMUNE PULMONARY ALVEOLAR PROTEINOSIS

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Abstract

Pulmonary alveolar proteinosis is a rare pulmonary syndrome characterized with accumulation of lipoprotein complexes in alveoli as a result of disturbance of utilization of surfactant by alveolar macrophages. Lack of pathognomonic symptoms and signs as well as pathological changes in routine examination methods is one of the reasons of its untimely diagnosis. The article presents a clinical case of a 51-year-old patient with progressive shortness of breath and ling infiltrates that were interpreted as a sign of bilateral pneumonia. High-resolution computer tomography of chest organs showed a typical pattern for this syndrome, so-called crazy paving (segments of pulmonary tissue induration, ground-glass opacity, with visualized reticular structures). Changes typical to alveolar proteinosis were also found when bronchoalveolar lavage was studied and lung diffusion capacity was evaluated.

About the authors

Vendi E.T. Kintana

People’s Friendship University of Russia

клинический ординатор, каф. внутренних болезней с курсом кардиологии и функциональной диагностики

Svetlana A. Rachina

People’s Friendship University of Russia

Email: Svetlana.Ratchina@antibiotic.ru
д-р мед. наук, проф. каф. внутренних болезней с курсом кардиологии и функциональной диагностики

Sergei N. Avdeev

Sechenov First Moscow State Medical University (Sechenov University)

чл.-кор. РАН, д-р мед. наук, проф., зав. каф. пульмонологии

Igor E. Tiurin

Russian Medical Academy of Continuous Professional Education

д-р мед. наук, проф., зав. каф. рентгенологии и радиологии

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