No 5 (2024)

Digital transformation allows you to achieve a competitive advantage in the market while reducing costs and expenses, but at the same time improving quality, which is a cornerstone aspect in the biotechnology industry. The pharmaceutical market is steadily growing, this is especially evident after the COVID-19 pandemic, which contributed to the emergence of a large number of drugs produced using digital twins. Doppelgangers are beginning to play an increasingly important role in biotechnological production, which has a positive effect on increasing company revenue, reducing costs, and improving production safety.

The purpose of this study is to analyze the current state of the biotechnology market, assess the prospects for the introduction of digital twins into production cycles, as well as identify key areas and trends in the biotechnology industry.

The article examines the cases of already successfully functioning digital counterparts, provides an analysis of the current state of the market and a forecast for its growth in the coming years. Special attention is paid to the new Pharma 4.0 concept and the effects that are designed to completely transform the industry with the help of digital technologies, the locomotive of which is the digital twin.

During the research, the authors relied on the scientific works of domestic and foreign scientists from Germany, China, the Netherlands, the Russian Federation, the USA, and South Korea. The information base was compiled by reports from big pharma companies, vendors of digital twin solutions, consulting companies: McKinsey, PwC, Pfizer, Merck, GlaxoSmithKline, Siemens, Aveva, Philips, AstraZeneca, statistical data Market.US , Yahoo.Finance, ISPE.

The article is devoted to the problem of strategic management of business systems in which the functions of an orchestrator are performed by an enterprise in the ICT sector. The purpose of the study is to identify types of strategies for organizing entrepreneurial ecosystems and describe their features in the context of the development of the digital economy. During the research process, a selection of 100 IT companies that were leaders in terms of revenue for 2021–2023 was studied. and their growth. Cluster analysis methods were used to test ecosystem criteria in relation to the ICT sector, typology methods and the construction of descriptive models.

Statistical analysis showed that despite the reduction in the number of enterprises, in modern conditions there has been a tendency to increase the share of enterprises in the ICT sector in the economy. During the study of a sample of IT companies – industry leaders, 5 clusters were formed, the most typical characteristics of which were used to identify distinctive features. It was found that 56% of the studied sample of IT enterprises become orchestrators for entrepreneurial ecosystems, which corresponds to clusters 1–4. As a result of the similarity analysis, it was determined that in practice the strategy of acceleration, partnership, integration and customer-oriented strategy is used. For each type of orchestrator strategy, models have been generated and key features have been identified. A customer-centric orchestrator strategy is the most preferable for rapid growth and scale-up.

The results obtained have important practical significance for organizing ecosystems with the leading role of the IT company orchestrator and choosing the most effective strategy. In further research, it is necessary to identify specific management actions and tools that are applicable for each type. In continuation, it is necessary to assess the productivity of ecosystems, taking into account the types of strategies and highlighting their competitive advantages.

The global electric vehicle market is increasing. The main motivation for switching to this innovative type of vehicle is, first of all, reducing the impact on the environment, reducing operating costs, the possibility of using new technologies in transport, etc. Of course, the development of electric vehicles, like other industries, has its problems. The paper examines the methodology for determining the optimal options for charging infrastructure for electric vehicles, as the main factor influencing the widespread use of electric cars. The purpose of the study is to determine the optimal option for mobile charging stations (MCS) for the conditions of Tajikistan based on a comparative analysis of key indicators: cost, weight and resource. To conduct a study to determine the optimal option for mobile charging stations, a comparative analysis method was used. For the conditions of Tajikistan, to determine the optimal option for mobile charging stations (MCS), a corresponding comparative analysis was carried out in terms of such indicators as cost, weight, and resource. It was revealed that the MCS based on autonomous generators with an internal combustion engine (ICE) is superior to other options in all respects. However, we should not forget that the greatest harm is caused to the environment by such an MCS, and it requires a constant supply of fuel. The best option is to combine lithium-ion batteries with an autonomous generator and a solar battery or wind power plant. Considering that the multi-station system is often located in one place, at the first stage it was proposed to create a multi-station station with an autonomous generator, lead-acid batteries, or a hybrid version. In the future, it is necessary to gradually switch to the joint use of hybrid installations based on lithium-ion batteries in combination with an internal combustion engine, solar panels, or a wind-electric installation. The practical significance of the study is to create a stable and cost-effective infrastructure for charging electric vehicles, including based on alternative energy sources, in Tajikistan, which contributes to increased mobility, economic development and environmental sustainability of the region. The development of electric vehicle infrastructure will stimulate the growth of the electric vehicle market, which in turn will contribute to the development of related economic sectors. Similar installations can be used in other industries, such as tourism, power supply to remote villages, and geological exploration.

One of the significant ways to reduce the destructive impact on the environment from the technological processes of restorative repair of car bodies is the transition to paints diluted with water. However, the direct use of existing paint drying chambers for the application and drying of waterborne paints can negatively affect the performance of the process and the quality of the coating. It has been established that during the drying of coatings from waterborne paints, the formation of stagnant ventilation zones is possible, which can lead to reverse condensation of water, followed by the formation of streaks.

The purpose of the study: to increase the efficiency of the process of painting automobile bodies with paints diluted with water, based on the control of the parameters of the air environment of the paint drying chambers.

Research methods: analysis of ventilation processes in existing paint-drying chambers and their compliance with the thermophysical and volatile properties of water vapor when painting automotive products.

In order to avoid the formation of stagnant zones of high humidity in the ceiling part of the paint and drying chambers, it is proposed to mount a system of guide plates, the purpose of which is to control the directions and speed of air flows in the painting and drying modes. To ensure acceptable technological and economic parameters of the process of painting with waterborne paints, depending on the humidity levels in the environment and in the working chamber of the paint and drying chambers, it is proposed to change the logic of the recirculation flap control. Dependencies linking the parameters of the movement of the executive bodies with the indicators of humidity, mode and direction of the flow of ventilated air are proposed.

The scientific novelty of the work lies in the methodology for controlling the humidity level, direction and mode of air flows in the working chamber of the paint and drying chambers, which eliminates the appearance of stagnant zones when painting car bodies with waterborne paints.

The direction of further research is to substantiate the optimal level of air humidity in the working chamber, depending on the state of the ambient air and the productivity of the painting process.

The article substantiates the topology of the brotherhood. The brotherhood is shown as a community based on a commonality of views and attitudes. N. F. Fedorov was the first thinker who, back in the 19th century, conceived the brotherhood community as a perfect community, and for all mankind. In Modern Philosophy, R. Barth and J. Agamben returned to the topic of the brotherhood community. Creating a perfect community is an urgent topic of our time. The purpose of the article is to model a perfect community based on the ideas of monastic brotherhood. As a result, the work shows that this community is generated by spiritual interaction and exists in a certain rhythm of its own (idiorhythm). The idiorhythm of the brothers, according to topological patterns, is expanded into a «house», and what is set in the rules in the behavior of the brothers is not just fulfilled by them, but is lived and transformed into a form of life. The scientific novelty lies in the topological orientation of the research. According to social topology, the realization of the «place» of time occurs through specific social interactions and practices. In understanding the scheme of sociality, we rely on the «ascending ontology» of M. Deland, which we complement with concepts such as «home» and «country». As a result, the scheme of sociality becomes as follows: «individuals – house – institutions – city – state – country». As the main conclusions, it is emphasized that fraternities are a perfect social form of community and are constructed in the form of «brothers – houses – practices – self-organizing and self-governing brotherhood – state – country». Interactions in the brotherhood are based on organic relationships, but nevertheless they carry the need for a state organization of communication between people who find themselves connected by spiritual solidarity, patriotic love, worthy and courageous deeds. Modernity has the character of a «posthuman sociality», people have to coexist with non–human beings – machines, robots, cyborgs and artificial intelligence. Humanity will be able to interact with artificial intelligence if it is spiritually transformed and is able to create a perfect community like a monastic brotherhood.

The subject of the research is the philosophical ancient Chinese traditional and modern innovative views on the anthropological problem of human existence in the aspect of lifestyle, aesthetic knowledge in the Confucian worldview. The motive for addressing the topic was the desire to trace and present a philosophical thought about the path of development of Chinese culture in approaching the aesthetics of life as an opportunity to achieve a wonderful life. The relevance of the problem lies in the promotion at the present stage of the value of the sensual principle competing with rationality in thinking. The novelty is the anthroposocioecological approach in the comparative analysis of ancient Chinese philosophical texts, in which the problem of ritual and music occupied a significant place, and the modern new Confucian philosophy, which highlighted the aesthetics of life. The author pays special attention to the aesthetic value of music in Chinese philosophy. Axiological, hermeneutic, phenomenological, and historical methods are used. The introduction gives a brief idea of the essence of the anthroposocioecological approach applicable to Chinese philosophy and the value of music in the aspect of research. n the new Confucian concept of aesthetics of life by the modern Chinese philosopher Liu Yuedi. In the author’s conclusions, the concept of new Confucianism, which puts forward the pursuit of an ideal life, seems to be a utopian and at the same time fruitful idea in search of self-sufficient personal and interpersonal satisfaction. Liu Yuedi’s philosophy highlights such basic anthropological problems as the Chinese concept of life, the difference between a good and a beautiful, wonderful life, the value of the sensory-emotional component; the Confucian psychoanalytic approach in the philosophy of music is asserted. From a practical point of view, the modern Chinese concept of aesthetics of life and its modeling of a beautiful lifestyle mean creating conditions under which everyone could create their lives freely, as an artist creates art. Attention is drawn to sensual and intellectual intuition in creative activity and to the difference in approaches in Chinese and European philosophy regarding lifestyle in the dynamics of cultural development.

The research is aimed at the historical and philosophical reconstruction of the problems of Gaudiya Vedanta theory of knowledge related to philosophizing, the concept of revelation and qualification (adhīkāra), in the philosophy of India of XVI–XX centuries. Gaudiya Vedanta, the philosophy of Gaudiya Vaishnavism, is the last independent branch of Vedanta in Indian philosophy, which summarizes in its texts the problems and solutions of previous Vedanta movements in the XVI century. The specificity of this school lies in the emphasis on personalism, ethics and aesthetics. The approach of «world philosophy» (F. I. Shcherbatskoy, V. K. Shokhin, R. V. Pshu) was used for the study, according to which in the philosophy of each developed culture we can find similar philosophical problems in varying degrees of elaboration in connection with a unique historical situation. Based on this approach, a historical and philosophical reconstruction of the hermeneutics of Gaudiya Vedanta is carried out, in which philosophizing is considered as the result of the process of revelation. The historical and philosophical analysis allowed us to identify two stages of the formation of the concept of revelation (śabda, śāstra, samādhi, veda) and qualification (adhīkāra) in Gaudiya Vedanta: classical (Jiva Gosvami and Krishnadas Kaviraja, Visvanatha Chakravarti XVI–XVII centuries), modern (Bhaktivinoda, Bhaktisiddhanta, Bhaktivedanta XIX–XX centuries). The analysis of historiography shows that Gaudiya Vedanta, using the apparatus of new logic (navya-nyaya), entered the age of globalization and accepted the challenges not only of the existing tradition of Indian philosophy, but also of European philosophy. For this purpose, the school used a system of interpretation and receiving revelations both inside and outside the sacred sphere with an expanded understanding of revelation and sacredness. In addition, Gaudiya Vedanta formulated special requirements for a thinker working with revelation. These requirements were supposed to preserve the uniqueness of the school and ensure intellectual continuity. They imply the need for the philosopher to have both some academic qualification (theology of the first order): knowledge of texts, their logic of explanation, prudence and insight, and spiritual qualifications (theology of the second order): morality, detachment and, in particular, sensitivity to religious emotions in relation to God. The historical and philosophical reconstruction allowed us to explicate a special model of philosophizing of Gaudiya Vedanta, based on revelation, personalistic theology, ethics and aesthetics. The results of the research can be useful for historians of Eastern philosophy with new material, analysis of concepts, explication of the role of historical and philosophical contexts.