Reproductive health of adolescent girls with overweight and obesity living in a large industrial region
- Authors: Antipov M.S.1,2, Zharkin N.A.3,2, Barinova I.A.2, Sherbakova S.V.2, Temirova D.B.2
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Affiliations:
- Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirsky
- Balashikha Regional Hospital
- Volgograd State Medical University
- Issue: Vol 11, No 2 (2024)
- Pages: 203-212
- Section: Original study articles
- URL: https://journal-vniispk.ru/2313-8726/article/view/260561
- DOI: https://doi.org/10.17816/aog623723
- ID: 260561
Cite item
Abstract
AIM: This study aimed to assess the reproductive health of adolescent girls with obesity living in a large industrial territory.
MATERIALS AND METHODS: A one-time study was conducted on 105 teenage girls aged 15–17 years. The main group consisted of 70 girls with overweight and obesity, who were divided into a group with menstrual irregularities (N1=42) and without disorders (N2=28). The control group included 35 girls with normal body weight and no menstrual irregularities. Morbidity was studied. Body mass index (BMI), pituitary (thyroid-stimulating hormone [TSH], follicle-stimulating hormone, and luteinizing hormone) and sex hormones (estradiol, DHEA-SO4, AMH, and testosterone), alanine aminotransferase, aspartate aminotransferase, total cholesterol, and ultrasound data of the thyroid gland and abdominal organs were determined. A quantitative assessment of treatment adherence and lifestyle modification was performed.
RESULTS: The average BMI values in the main and control groups were 31.1 (4.9) and 20.0 (1.9) kg/m2, respectively (p <0.001). A statistically significant predominance of the incidence of cardiovascular pathologies was found in the main group (χ2=2.58, p=0.014; OR=5.7; 95% CI, 1.2–26.2), as well as a more frequent occurrence of urinary tract, nervous system, and endocrine diseases. In the main group, echographic signs of liver and pancreatic pathologies were detected in 22 (31.4%) girls and diffuse changes in the thyroid gland in combination with cystic formations or hypoplasia in 31 (44.0%). The number of antral follicles was normal in all patients. A statistically significant difference in TSH (p <0.001), LH (p=0.015), and DHEA-SO4 (p=0.002) was obtained between the main and control groups. Adolescents aged 15 years were more adherent to treatment (χ2=13.28; p=0.003).
CONCLUSION: Statistically significant differences in clinical and laboratory data and treatment adherence were found in adolescent girls with overweight and obesity living in a large industrial region when compared with healthy girls, which dictates the need to improve and implement personalized medical and psychological programs.
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##article.viewOnOriginalSite##About the authors
Mikhail S. Antipov
Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirsky; Balashikha Regional Hospital
Email: info@balob.ru
ORCID iD: 0000-0003-2621-9417
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, Moscow; Moscow regionNikolay A. Zharkin
Volgograd State Medical University; Balashikha Regional Hospital
Author for correspondence.
Email: zharkin55@mail.ru
ORCID iD: 0000-0002-8094-0427
SPIN-code: 6309-0515
Scopus Author ID: 6602293084
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Volgograd; Moscow regionIrina A. Barinova
Balashikha Regional Hospital
Email: barinova.vsmu@gmail.com
ORCID iD: 0000-0001-5384-5208
MD, obstetrician-gynecologist
Russian Federation, Moscow regionSvetlana V. Sherbakova
Balashikha Regional Hospital
Email: info@balob.ru
ORCID iD: 0009-0004-5640-6306
MD, Deputy Chief Physician for Childhood and Obstetrics
Russian Federation, Moscow regionDiana B. Temirova
Balashikha Regional Hospital
Email: info@balob.ru
ORCID iD: 0009-0009-4681-6893
MD, Head of the Pediatric Department
Russian Federation, Moscow regionReferences
- Rostovskiy RV. The reproductive potential of the youth. Herald of Vyatka State University. 2012;(4–4):122–124. EDN: SJICDJ
- Gladkaya VS, Gricinskaya VL, Medvedeva NN. The modern trends in reproductive health and reproductive behavior of the female population in Russia. Mother and Baby in Kuzbass. 2017;(1):10–15. EDN: YFUHAD
- Kamaeva IA, Pavlov DS, Kazmin AS. Obesity like the reason of failure reproductive function. Molodoi uchenyi. 2016;(26–2):18–20 (In Russ.) EDN: XEODAZ
- Ivanova EA, Radinova SB. Obesity as risk factor of violation of reproductive function of the woman. Dnevnik nauki. 2019;(3):4. EDN: ZEKKVV
- Bistrickaya TS, Filatov SA, Lisyak DS, et al. Reproductive potential girls and girls-teenagers Amur Region. Amurskii meditsinskii zhurnal. 2014;(2):42–46. EDN: UANNUX
- Kazakova PA, Orlik LK. Reproductive behavior of the Russian population. Problem of risen age of motherhood in Russia. In: Cifrovizacia v usloviyah pandemii: missia socialnogo univesiteta buducshego: Sb. Mat. XXI mezhdunarodnogo kongressa. Moscow; 2022:146–154 (In Russ.) EDN: CBTPAY
- Bekbaeva IV, Mukovnikova EV, Kirtikiv SI, et al. Reproductive potential of obese women. Obstetrics and Gynecology. News. Views. Education. 2023;11:(S):126–131. EDN: YCNJTQ doi: 10.33029/2303-9698-2023-11-suppL-126-131
- Makarova EL, Olina AA, Padrul MM. Assessing risk factors that can cause overweight and obesity in women of reproductive age. Health Risk Analysis. 2020;(2):38–46. EDN: ZIUKYQ doi: 10.21668/health.risk/2020.2.04
- Rychkova LV, Ajurova ZG, Pogodina AV. Obesity and associated risk factors in adolescents in rural areas of Buryatia. Obesity and Metabolism. 2018;15(3):42–48. EDN: YOCACD doi: 10.14341/omet9532
- Taheri R, Mesbah Ardekani F, Raeisi Shahraki H, et al. Nutritional status and anthropometric indices in relation to menstrual disorders: a cross-sectional study. J Nutr Metab. 2020;2020:5980685. doi: 10.1155/2020/5980685
- Gricinskaya VL, Novikova VP, Khavkin AI. On the epidemiology of obesity in children and adolescents (systematic review and meta-analysis of scientific publications over a 15-year period). Clinical Practice in Pediatrics. 2022;17(2):126–135. EDN: BTFVGE doi: 10.20953/1817-7646-2022-2-126-135
- Bocharova OV, Teplyakova ED. Children and adolescents’ obesity is the 21st century health problem. Kazan Medical Journal. 2020;101(3):381–388. EDN: OQOFWC doi: 1017816/KMJ2020-381
- Svidinskaya EA, Ageev MB, Paleeva NV, et al. Menstrual dysfunction in adolescent girls who are overweight: a literature review. V.F. Snegirev Archives of Obstetrics and Gynecology. 2022;9(2):93–101. EDN: HXDYEZ doi: 10.17816/2313-8726-2022-9-2-93-10
- On the procedure for preventive medical examinations of minors: Order of the Ministry of Health of the Russian Federation dated 08.10.2017 No. 514Н. (In Russ.)
- Obesity in children: clinical recommendations of the Russian Federation 2021. Russian Association of Endocrinologists. Approved by the Ministry of Health of the Russian Federation in 2021. (In Russ.)
- Nikolaev NA, Skirdenko YuP, Pavlinova EB, et al. Questionnaire for quantitative assessment of treatment adherence: modification for adolescents 15–17 years, validation and reliability assessment. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2022;67(5):72–77. doi: 10.21508/1027-4065-2022-67-5-72-77
- Adherence to treatment. Russian National Guidelines. Ed. by NA Nikolaev, AI Martynov, YuP Skirdenko. Moscow: Publishing House of the Academy of Natural Sciences; 2022. (In Russ.) doi: 10.17513/np.541
- Rashka C. Python and machine education. Moscow: DMK Press; 2017.
- Karakhalis LYu, Burluckaya AV, Sutovskaya DV, Steblo EI. Effect of body weight on somatic and reproductive health of adolescents. Pediatric and Adolescent Reproductive Health. 2018;14(3):51–57. doi: 10.24411/1816-2134-2018-13004
- Garoufi F, Pagoni A, Papadaki M, et al. Cardiovaskular Risk Factors and Subclinial Atherosclerosis in Greek Adolescents with Polycystic Ovarian Syndrome: Its Relationship with Body Mass Index. Children (Basel). 2021;9(1):4. doi: 10.3390/children9010004
- Metwalley KA, Farghaly HS, Tamer DM, et al. Ovarian reserve in adolescent girls with autoimmune thyroiditis. Arch Endicrinol Metab. 2023;67(3):395–400. doi: 10.20945/2359-3997000000597
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