Characteristics of cervical biopsy during pregnancy
- Authors: Rosyuk E.A.1,2, Oboskalova T.A.1, Shtanova A.A.1, Sarapulova A.S.1, Filatov A.E.1, Neff E.I.2, Verba T.E.2
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Affiliations:
- Ural State Medical University
- Yekaterinburg Clinical Perinatal Center
- Issue: Vol 12, No 1 (2025)
- Pages: 75-83
- Section: Original study articles
- URL: https://journal-vniispk.ru/2313-8726/article/view/310010
- DOI: https://doi.org/10.17816/aog633197
- ID: 310010
Cite item
Abstract
BACKGROUND: Abnormal cervical cytology results occur in two out of every 100 pregnant women, a rate comparable to that in their nonpregnant peers. Histopathological examination of biopsy specimens is warranted only in cases of suspected invasive disease. Overall, cervical biopsy during pregnancy is rarely performed and is indicated only under strict clinical criteria, typically carried out by an experienced specialist, often in a hospital setting.
AIM: To evaluate the procedural characteristics of cervical biopsy and the histopathological findings in biopsy specimens obtained during pregnancy.
MATERIALS AND METHODS: This study included 28 patients divided into two groups: group 1 (n=13), pregnant patients who underwent cervical biopsy, and group 2 (n=15), nonpregnant patients who underwent the procedure. The indications for biopsy and the procedural techniques were analyzed in both study groups. Comparative statistical analysis was performed using Microsoft Excel, with statistical significance assessed using Pearson’s chi-square test. The results were considered statistically significant at p < 0.05.
RESULTS: Comparative analysis of histopathological findings revealed no statistically significant differences in the detection rates of CIN I, CIN II, or CIN III between the groups. However, cervical leukoplakia was significantly more common in group 2 (14 cases, 93.3%), whereas no cases were recorded in group 1 (p=0.003). Nabothian cysts were identified in four cases (30.8%) in group 1 but were absent in group 2 (p=0.045). Dyskeratosis was observed only in group 1 (5 cases, 38.5%), whereas no cases were reported in group 2 (p=0.027).
CONCLUSION: Cervical biopsy during pregnancy is distinguished by the absence of anesthesia, the frequent use of targeted rather than multifocal biopsy, the omission of cervical canal curettage, and the need for prolonged hemostasis. Moreover, cervical biopsy performed during pregnancy is more frequently associated with CIN III histopathological findings (61.5%).
Full Text
##article.viewOnOriginalSite##About the authors
Elena A. Rosyuk
Ural State Medical University; Yekaterinburg Clinical Perinatal Center
Author for correspondence.
Email: elenakdc@yandex.ru
ORCID iD: 0000-0003-1303-3955
SPIN-code: 9056-0640
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, 3 Repina st, Yekaterinburg, 620028; YekaterinburgTatyana A. Oboskalova
Ural State Medical University
Email: oboskalova.tat@yandex.ru
ORCID iD: 0000-0003-0711-7896
SPIN-code: 9364-2321
MD, Dr. Sci. (Medicine), Professor
Russian Federation, 3 Repina st, Yekaterinburg, 620028Alexandra A. Shtanova
Ural State Medical University
Email: alekshtanova@gmail.com
ORCID iD: 0000-0002-8104-0017
SPIN-code: 1086-9994
Student
Russian Federation, 3 Repina st, Yekaterinburg, 620028Arina S. Sarapulova
Ural State Medical University
Email: arishhhka@gmail.com
ORCID iD: 0009-0005-8974-8692
Student
Russian Federation, 3 Repina st, Yekaterinburg, 620028Artyom E. Filatov
Ural State Medical University
Email: fun.art.can@gmail.com
ORCID iD: 0000-0002-2000-2965
Student
Russian Federation, 3 Repina st, Yekaterinburg, 620028Ekaterina I. Neff
Yekaterinburg Clinical Perinatal Center
Email: 9222241411@mail.ru
ORCID iD: 0009-0000-5312-1007
MD, Cand. Sci. (Medicine)
Russian Federation, YekaterinburgTatyana E. Verba
Yekaterinburg Clinical Perinatal Center
Email: elenakdc@yandex.ru
ORCID iD: 0009-0008-4087-0007
Obstetrician-Gynecologist
Russian Federation, YekaterinburgReferences
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