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Modern problems of preclinical studying feed additives for animals and ways to solve them
- Authors: Rakhmatullin E.K.1, Kadikov I.R.1, Kurshakova E.I.1, Sagdeev D.R.1, Korchemkin A.A.1, Vafin I.F.1, Galyautdinova G.G.1, Malanev A.V.1, Yamalova G.R.1, Khalikova K.F.1
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Affiliations:
- Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
- Issue: No 2 (2024)
- Pages: 79-83
- Section: Zootechnics
- URL: https://journal-vniispk.ru/2500-2082/article/view/255725
- DOI: https://doi.org/10.31857/S2500208224020169
- ID: 255725
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Abstract
Resource-saving technology in agriculture is the use of stimulating additives in animal feeding rations that promote better absorption of feed. One of the measures to prevent toxicosis in industrial livestock and poultry farming is to determine the toxicity of feed. The variety of existing methods makes it possible to determine the level and class of drug toxicity at the initial stage. In the developed classification for veterinary drugs, the cumulation coefficient, therapeutic breadth index and dose level of toxic effect are used, which makes it possible to predict the nature and degree of their danger at the stage of preclinical study of feed additives. To determine the listed indicators, it is necessary to establish LD50 and the cumulation coefficient. Since feed additives are introduced into the body through the digestive tract, during preclinical studies they are studied and classified according to their hepatotoxic effect. Bilirubin, albumin, and enzyme activity contained in the blood (glutamate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and the ratio of alanine aminotransferase to alkaline phosphatase) are used as markers. It is necessary to determine the de Ritis, Schmidt coefficient and the R index. This will minimize the intake of toxic feed additives into the animals’ bodies and will contribute to an increase in their productivity.
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About the authors
E. K. Rakhmatullin
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Author for correspondence.
Email: amil59@yandex.ru
Grand PhD in Veterinary Sciences
Russian Federation, Kazan, Republic of TatarstanI. R. Kadikov
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Email: amil59@yandex.ru
Grand PhD in Biological Sciences
Russian Federation, Kazan, Republic of TatarstanE. I. Kurshakova
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Email: amil59@yandex.ru
PhD in Biological Sciences
Russian Federation, Kazan, Republic of TatarstanD. R. Sagdeev
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Email: amil59@yandex.ru
PhD in Veterinary Sciences
Russian Federation, Kazan, Republic of TatarstanA. A. Korchemkin
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Email: amil59@yandex.ru
PhD in Biological Sciences
Russian Federation, Kazan, Republic of TatarstanI. F. Vafin
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Email: amil59@yandex.ru
PhD in Biological Sciences
Russian Federation, Kazan, Republic of TatarstanG. G. Galyautdinova
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Email: amil59@yandex.ru
PhD in Biological Sciences
Russian Federation, Kazan, Republic of TatarstanA. V. Malanev
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Email: amil59@yandex.ru
PhD in Biological Sciences
Russian Federation, Kazan, Republic of TatarstanG. R. Yamalova
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Email: amil59@yandex.ru
Junior Researcher
Russian Federation, Kazan, Republic of TatarstanK. F. Khalikova
Federal Center for Toxicological, Radiation and Biological Safety of the Russian Federation
Email: amil59@yandex.ru
PhD in Veterinary Sciences
Russian Federation, Kazan, Republic of TatarstanReferences
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