Email this article Technologies and Perspectives of Liposomal Drug Application in Clinical Practice
- Authors: Krasnopolskii Y.M.1,2, Grigor’eva A.S.3, Katsai A.G.4, Konakhovich N.F.3, Prokhorov V.V.5, Stadnichenko A.V.4, Balaban’yan V.Y.1, Lyutik A.I.6, Shvets V.I.1,6,7
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Affiliations:
- LLC “Drugs Technology”
- National Technical University “Kharkiv Polytechnic Institute”, Ministry of Education and Science of Ukraine
- Institute of Pharmacology and Toxicology
- National Pharmaceutical University, Ministry of Healthcare of Ukraine
- OOO Nanomedtekh
- Moscow State University of Fine Chemical Technologies, Ministry of Education and Science of the Russian Federation
- Research Institute of General Pathology and Pathophysiology
- Issue: Vol 12, No 7-8 (2017)
- Pages: 461-470
- Section: Article
- URL: https://journal-vniispk.ru/2635-1676/article/view/220155
- DOI: https://doi.org/10.1134/S1995078017040139
- ID: 220155
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Abstract
In this article the results from studies of liposomes with the inclusion of active pharmacological substances (irinotecan, oxaliplatin, cytochrome C, doxorubicin, quercetine, etc.) in lipid nanoparticles are introduced. The key techniques of adding substances to liposomes are observed: the lipid-film method and the gradient and chemical-bond methods. The main conditions for the inclusion of drugs in liposomes are presented. Questions of determining the inclusion in liposomes and the synthesis and control of the liposomal drugs are discussed. The synthesized drugs are currently undergoing preclinical and clinical trials. Some of the proposed drugs have already been registered and have been used in medical practice for more than 25 years.
About the authors
Yu. M. Krasnopolskii
LLC “Drugs Technology”; National Technical University “Kharkiv Polytechnic Institute”, Ministry of Education and Science of Ukraine
Author for correspondence.
Email: shvetsviiv@gmail.com
Russian Federation, Khimki, Moscow oblast, 141400; Kharkiv, 61002
A. S. Grigor’eva
Institute of Pharmacology and Toxicology
Email: shvetsviiv@gmail.com
Ukraine, Kiev, 03057
A. G. Katsai
National Pharmaceutical University, Ministry of Healthcare of Ukraine
Email: shvetsviiv@gmail.com
Ukraine, Kharkiv, 61002
N. F. Konakhovich
Institute of Pharmacology and Toxicology
Email: shvetsviiv@gmail.com
Ukraine, Kiev, 03057
V. V. Prokhorov
OOO Nanomedtekh
Email: shvetsviiv@gmail.com
Ukraine, Kiev, 03680
A. V. Stadnichenko
National Pharmaceutical University, Ministry of Healthcare of Ukraine
Email: shvetsviiv@gmail.com
Ukraine, Kharkiv, 61002
V. Yu. Balaban’yan
LLC “Drugs Technology”
Email: shvetsviiv@gmail.com
Russian Federation, Khimki, Moscow oblast, 141400
A. I. Lyutik
Moscow State University of Fine Chemical Technologies, Ministry of Education and Science of the Russian Federation
Email: shvetsviiv@gmail.com
Russian Federation, Moscow, 119571
V. I. Shvets
LLC “Drugs Technology”; Moscow State University of Fine Chemical Technologies, Ministry of Education and Science of the Russian Federation; Research Institute of General Pathology and Pathophysiology
Email: shvetsviiv@gmail.com
Russian Federation, Khimki, Moscow oblast, 141400; Moscow, 119571; Moscow, 125315
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