Email this article Functional reserves and adaptive capabilities of the body in conditions of oxidative stress
- Authors: Nesteruk A.V.1, Shalimov P.M.1, Grebennikov N.B.1, Vengerovich N.G.2,3, Ustinova T.M.2
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Affiliations:
- Federal State Unitary Enterprise “Scientific Center “Signal”
- State Research and Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation
- Saint Petersburg State Chemical and Pharmaceutical University
- Issue: Vol 6, No 4 (2024)
- Pages: 10-17
- Section: Pharmaceutical Sciences
- URL: https://journal-vniispk.ru/PharmForm/article/view/280537
- DOI: https://doi.org/10.17816/phf641687
- ID: 280537
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Abstract
The review is devoted to the problem of forming functional reserves and increasing the adaptive capabilities of the human body to the action of negative factors of various nature, including those accompanied by violations of the antioxidant status. Functional reserves are determined by the metabolic and bioenergetic capabilities of the body, as well as the possibility of interaction of organs and body systems for self-regulation and optimization of its physiological functions. The levels of functional reserves determine the body’s ability to adapt urgently or long-term. Oxidative stress is a non–specific pathogenetic process that develops as a result of a sharp increase in oxidative (free radical, peroxide) processes with insufficient functioning of the endogenous antioxidant system of the body. Almost all pathological conditions are more or less accompanied by the development of oxidative stress, which determines the relevance and prospects of this study. Urgent and long-term compensatory mechanisms in oxidative stress are associated with the optimization of cellular energy supply and the state of the endogenous antioxidant system of the body, in which a special role belongs to the correction of mitochondrial disorders. Ensuring the functional capabilities of the body for urgent adaptation is possible using a complex of pharmacological preparations of multifunctional action based on antioxidants. Increasing the effectiveness of the formation of long-term adaptation is advisable due to the moderate and short-term effect of prooxidants on the body, for example, in widespread hypoxic training.
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##article.viewOnOriginalSite##About the authors
Alexander V. Nesteruk
Federal State Unitary Enterprise “Scientific Center “Signal”
Email: a.nesteruk@ncsignal.ru
Candidate of Technical Sciences, Head of the Department of the Federal State Unitary Enterprise “Scientific Center “Signal”
Russian Federation, MoscowPavel M. Shalimov
Federal State Unitary Enterprise “Scientific Center “Signal”
Email: p.shalimov@ncsignal.ru
acad. RAEN, Doctor of Medical Sciences, Professor, Chief Researcher of the Federal State Unitary Enterprise “Scientific Center “Signal”
Russian Federation, MoscowNikolay B. Grebennikov
Federal State Unitary Enterprise “Scientific Center “Signal”
Email: n.grebennikov@ncsignal.ru
Researcher at the Federal State Unitary Enterprise “Scientific Center “Signal”
Russian Federation, MoscowNikolay G. Vengerovich
State Research and Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation; Saint Petersburg State Chemical and Pharmaceutical University
Author for correspondence.
Email: nickolai.vengerovich@pharminnotech.com
Doctor of Medical Sciences, Associate Professor, Head of the Department of the State Research and Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation; Professor of the Industrial Ecology Department, Saint Petersburg State Chemical and Pharmaceutical University of the Ministry Health of the Russian Federation
Russian Federation, Saint Petersburg; Saint PetersburgTatyana M. Ustinova
State Research and Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation
Email: gniiivm_5@mail.ru
Researcher Head of the Department
Russian Federation, Saint PetersburgReferences
- Dictionary of physiological terms (ed. by O. G. Gazenko). – Moscow: Nauka, 1987. – 446 p.
- Davidenko D. N. Functional reserves of adaptation of the human body // Social physiology: textbook. – 1996. – pp. 126–135.
- Kurzanov A. N., Zabolotskikh N. V., Manuilov A. M. Clinical and physiological aspects of the diagnosis of functional reserves of the body. // Kuban Scientific Medical Bulletin. – 2015. – № 6 (155). – Pp. 73–77.
- Kurzanov A. N., Zabolotskikh N. V., Kovalev D. V. Functional reserves of the body: monograph / A. N. Kurzanov, N. V. Zabolotskikh, D. V. Kovalev – M.: Publishing House of the Academy of Natural Sciences, 2016. – 96 p.
- Ushakov I. B., Shalimov P. M. Functional reliability and functional reserves of the pilot // Bulletin of the Russian Academy of Medical Sciences. – 1996. – No. 7. – pp. 26–31.
- Kurzanov A. N. Functional reserves of the body in the perspective of clinical physiology // Modern problems of science and education. – 2015. – No. 4. – pp. 24–27.
- Glazachev O. S. Kryzhanovskaya S.Yu. Adaptive medicine: a strategy for psychophysiological adaptation of a person to a critically altered environment // Bulletin of the International Academy of Sciences (Russian section). – 2019. – No. 1. – pp. 48–55.
- Hussain J., Cohen M. Clinical Effects of Regular Dry Sauna Bathing. // A Systematic Review. Evidence-Based Complementary and Alternative Medicine. –2018. – P. 37–49. (In Russ).
- Sosin D. V. Pharmacological correction of acute exogenous hypoxia with antihypoxants. / D. V. Sosin, A. V. Evseev, V. A. Pravditsev et al. / Bulletin of the Smolensk State Medical Academy. – 2015. – Vol. 14, No. 1. – pp. 46–71.
- Verges S., Chacaroun S., Godin Ribuot D., Baillieul S. Hypoxic conditioning as a new therapeutic modality // Front. Pediatr. – 2015. – V. 3. – pp. 58–67. (In Russ).
- Churilova A. V., Glushchenko T. S., Vetrovoy O. V., Sarieva K. V., Rybnikova E. A., Tyulkova E. I., Samoilov M. O. Modification of histone acetylation by hypoxic postconditioning: the use of histone deacetylase inhibitors as a method of pharmacological correction of posthypoxic pathologies // Materials of the XXIII Congress of the I. P. Pavlov Physiological Society with international participation. – 2017. – pp. 676–678.
- Bouchama A., Aziz M. A., Mahri S. A., Gabere M. N., Dlamy M. A. et al. Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat Stress // Scientific Reports. – 2017. – V. 7 – pp. 9429–9437. (In Russ).
- Ran K., Xu H., Lu A. et al. Hypoxia preconditioning in the brain // Dev. Neurosci. – 2005. – V. 27. – P. 87–92. (In Russ).
- Gening T. P., Ivanskaya H. H. Metabolic pathways of oxygen utilization and ATP production in liver tissue in acute circulatory hypoxia // Vestn. new medical technologies. – 2006. – T.XIII, No. 3. – pp. 32–34.
- Dolgikh V. T., Larin A. I., Pilipchuk I. A. Metabolic disorders in critical conditions // Polytrauma. – 2007. – No. 3. – pp. 73–78.
- Horowitz M. Epigenetics and cytoprotection with heat acclimation // J. Appl Physiol. – 2016. – V. 120. – P. 702–710. (In Russ).
- Hurtsilava O. G. Oxidative stress and inflammation: pathogenetic partnership: monograph / O. G. Hurtsilava, N. N. Pluzhnikov, Ya.A. Nakatis. – St. Petersburg: Publishing House of I. I. Mechnikov NWSMU, 2012. – 340 p.
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