Email this article Generalized data of criteria of risk factors for the use of the drug torasemide from the materials of its preclinical studies
- Authors: Anisimova N.A.1, Selizarova N.O.1, Plisko G.A.1, Semivelichenko E.D.1, Napalkova S.M.1
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Affiliations:
- Saint Petersburg State Chemical and Pharmaceutical University
- Issue: Vol 2, No 4 (2020)
- Pages: 18-26
- Section: Pharmaceutical Sciences
- URL: https://journal-vniispk.ru/PharmForm/article/view/50500
- DOI: https://doi.org/10.17816/phf50500
- ID: 50500
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Abstract
Thе article reviewed, analyzed and summarized the results of experimental (preclinical) pharmacological studies of the drug Torsemide. Torsemide is the first of the new generation of loop diuretics, which fundamentally differs from the first generation of loop diuretics in the spectrum of pharmacological effects.
The present review considers safety aspects, pharmacokinetics, pharmacodynamics of Torsemide found in various studies in preclinical research. Information on the effectiveness of Torsemide- based preparations in the treatment of chronic heart failure and arterial hypertension is given in the relevant sections of the article.
The search for information sources for the review was carried out using domestic and international databases elibrary and PubMed, applying contextual queries, including international non-proprietary names, terms of preclinical studies of pharmacokinetics, pharmacodynamics, and animal species used.
The summarized data presented in the study, in our opinion, may be used by researchers who are engaged in preclinical and clinical studies, as well as the issues of studying the efficacy and safety of generic drugs used in the treatment of patients with arterial hypertension and other cardiovascular pathology.
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##article.viewOnOriginalSite##About the authors
Natalia A. Anisimova
Saint Petersburg State Chemical and Pharmaceutical University
Email: natalia.anisimova@pharminnotech.com
PhD in Biological Sciences at the Department of Pharmacology and Clinical Pharmacology
Russian Federation, 197376, St. Petersburg, Professora Popova st., 14Natalia O. Selizarova
Saint Petersburg State Chemical and Pharmaceutical University
Email: selizarova@pharminnotech.com
PhD in Medicine at the Department of Pharmacology and Clinical Pharmacology
Russian Federation, 197376, St. Petersburg, Professora Popova st., 14Grigory A. Plisko
Saint Petersburg State Chemical and Pharmaceutical University
Email: grigoriy.plisko@pharminnotech.com
Junior Researcher, Center for Experimental Pharmacology
Russian Federation, 197376, St. Petersburg, Professora Popova st., 14Evgeny D. Semivelichenko
Saint Petersburg State Chemical and Pharmaceutical University
Email: evgeniy.semivelichenko@pharminnotech.com
Junior Researcher, Center for Experimental Pharmacology
Russian Federation, 197376, St. Petersburg, Professora Popova st., 14Svetlana M. Napalkova
Saint Petersburg State Chemical and Pharmaceutical University
Author for correspondence.
Email: svetlana.napalkova@pharminnotech.com
PhD in Biological Sciences, Professor, Professor at the Department of Pharmacology and Clinical Pharmacology
Russian Federation, 197376, St. Petersburg, Professora Popova st., 14References
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