Email this article Effect of organophosphorus compounds on the external respiratory functionin rats during intratracheal andintraperitonealadministration
- Authors: Kryazhevskikh A.A.1,2, Kryazhevskikh A.A.1,2, Subbotina S.N.1, Sklyarova N.A.2
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Affiliations:
- State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation
- Saint Petersburg State Chemical and Pharmaceutical University
- Issue: Vol 3, No 2 (2021)
- Pages: 60-65
- Section: Biomedical Sciences
- URL: https://journal-vniispk.ru/PharmForm/article/view/72068
- DOI: https://doi.org/10.17816/phf72068
- ID: 72068
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Abstract
Due to the increasing influence of chemical factors on the human body, the experiment has been conducted using organophosphorus compounds (OPC) to stimulate poisoning cases in the production facilities. Given that the development of respiratory failureis a specific organophosphate poisoningsymptom, a comparative analysis of external respiratory function (ERF)in rats with intratracheal and intraperitoneal administration of diisopropyl fluorophosphates (DFP) has been carried out. During the research, the average lethal doses of the toxic chemicals have been established, the conditions of DFP intoxication have been modeled.Thus, LD16 was 0.284 mg/kg by intratracheal administration, 1.6 mg/kg – byintraperitoneal administration. Experimental data have shown that the intratracheal intake of OPC causes the development of respiratory failure in the first minutes after poisoning.The return of the ERF indicators to the background values was noted a day after poisoning. With the intraperitoneal administration of the toxic chemical, the rate of development of ERF disorders was lower, toxic effects persisted for two days. The data obtained can be used to make appropriate recommendations for the prevention of accidents and non-emergency cases in a production facility.
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##article.viewOnOriginalSite##About the authors
Anastasiya A. Kryazhevskikh
State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation; Saint Petersburg State Chemical and Pharmaceutical University
Email: gniiivm_15@mil.ru
Research Assistantat the Research Department, State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation, Master Student, Saint Petersburg State Chemical and Pharmaceutical University
Russian Federation, Saint Petersburg; Saint PetersburgAleksey A. Kryazhevskikh
State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation; Saint Petersburg State Chemical and Pharmaceutical University
Email: gniiivm_15@mil.ru
Research Assistant at the Research Department, State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation, Master Student, Saint Petersburg State Chemical and Pharmaceutical University
Russian Federation, Saint Petersburg; Saint PetersburgSvetlana N. Subbotina
State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation
Email: gniiivm_15@mil.ru
SPIN-code: 7249-8174
Ph. D. In Biology, Senior Researcher at the Research Department
Russian Federation, Saint PetersburgNataliya A. Sklyarova
Saint Petersburg State Chemical and Pharmaceutical University
Author for correspondence.
Email: natalia.sklyarova@pharminnotech.com
SPIN-code: 9473-6506
Ph. D. in Engineering Sciences, Associate Professorat the Industrial Ecology Department
Russian Federation, Saint PetersburgReferences
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