Early onset of cardiovascular disorders in children: risk factors and long-term consequences
- Authors: Ryazanova T.A.1, Ustyuzhanina M.A.1, Kovtun O.P.1, Brodovskaya T.O.1
-
Affiliations:
- Ural State Medical University
- Issue: Vol 28, No 4 (2024)
- Pages: 50-61
- Section: Review
- URL: https://journal-vniispk.ru/RFD/article/view/280659
- DOI: https://doi.org/10.17816/RFD634603
- ID: 280659
Cite item
Abstract
Cardiovascular diseases (CVD), including myocardial infarction and stroke, remain the leading cause of morbidity and mortality in industrialized nations. This review highlights studies demonstrating that adverse prenatal factors play a significant role in determining cardiovascular health and contribute to the early development of subclinical atherosclerosis in children and adolescents. Indirect evidence of early atherosclerosis in children can be obtained through non-invasive imaging of vascular changes, such as anatomical alterations (e.g., increased intima-media thickness), mechanical changes (e.g., increased arterial stiffness), and physiological changes (e.g., reduced flow-mediated dilation). Effective early identification of individuals, particularly children, at an increased risk of future cardiovascular diseases is critical for prevention. Existing algorithms for assessing CVD risk or stages primarily rely on “traditional” risk factors. However, these algorithms often fail to accurately detect atherosclerosis in young individuals and are unsuitable for pediatric use, emphasizing the need for alternative methods to classify risk in asymptomatic young patients. This article provides an overview of such methodologies.
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##article.viewOnOriginalSite##About the authors
Tatyana A. Ryazanova
Ural State Medical University
Email: tatianadgb11@mail.ru
ORCID iD: 0000-0002-2332-8602
Russian Federation, 3 Repina St., Yekaterinburg, 620028
Margarita A. Ustyuzhanina
Ural State Medical University
Author for correspondence.
Email: ustmargarita@mail.ru
ORCID iD: 0000-0002-4285-6902
SPIN-code: 5438-4476
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, 3 Repina St., Yekaterinburg, 620028Olga P. Kovtun
Ural State Medical University
Email: usma@usma.ru
ORCID iD: 0000-0002-5250-7351
SPIN-code: 9919-9048
MD, Dr. Sci. (Medicine), Professor, Academician of the RAS
Russian Federation, 3 Repina St., Yekaterinburg, 620028Tatyana O. Brodovskaya
Ural State Medical University
Email: tbrod80@gmail.com
ORCID iD: 0000-0002-2847-4422
SPIN-code: 7798-7054
MD, Dr. Sci. (Medicine), Assistant Professor
Russian Federation, 3 Repina St., Yekaterinburg, 620028References
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