Analysis of data on phytophotodermatitis caused by contact with the sap of plants of the genus Hogweed (Heracleum L.)

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Abstract

The rapid spread of overgrowth of plants of the genus Hogweed, associated with their use as an agricultural fodder crop, is currently a serious problem for the Russian Federation. This process has a negative impact on the biodiversity of the vegetation cover, destroying natural ecosystems and causing significant economic damage. However, the active spread of hogweeds on the territory of the Russian Federation would not be so catastrophic if it were not for their aggressive properties: in contact with the skin, plant sap causes phytophotodermitis, which is a burn similar to thermal burns of I, II and III degrees. The article considers qualitative and quantitative composition of the main biologically active substances of hogweeds sap and shows that the biologically active substances causing phytophotodermatitis are furanocoumarins. It has been established that the pronounced photosensitizing activity of furanocoumarins is determined by the presence of a furan ring at positions 6,7 and 7,8 of coumarin. Such compounds include psoralen and its main derivatives: xanthotoxin, bergapten, bergamotin, imperatorin, isopimpinellin and angelicin (isopsoralen) and its main derivatives: sfondin, pimpinellin, isobergapten. Substitution of furan ring condensed with coumarin ring as well as change of its position leads to loss of photosensitizing activity. It was determined that the activity of plant sap of the genus Hogweed is in direct dependence on such factors as qualitative and quantitative content of furanocoumarins in the plant sap, the amount of sap and the area of the skin lesion zone, the time of contact of the affected skin areas with the plant sap, the intensity of ultraviolet irradiation and the time of its effect on the affected areas, as well as the peculiarities of each person (e.g., age, skin phototype). The methods of standard therapy of three clinical forms of phytophotodermatitis were analyzed. It was found that currently no specific clinical recommendations for the diagnostics and treatment of phytophotodermatitis resulting from contact with the sap of hogweeds. At the end of the article, the conclusion is formulated that one of current and promising tasks of pharmaceutical technology may be the development of drugs used in the treatment of burns caused by the sap of plants of the genus Hogweed, taking into account the mechanism of action of furanocoumarins.

About the authors

Ekaterina A. Klimkina

Military Medical Academy

Author for correspondence.
Email: vmeda-nio@mail.ru
ORCID iD: 0000-0002-3391-7208
SPIN-code: 9298-8619

MD, Cand. Sci. (Pharmaceuticals), Associate Professor of the Pharmacy Department

Russian Federation, Saint Petersburg

Marina S. Okolelova

Military Medical Academy

Email: vmeda-nio@mail.ru
ORCID iD: 0009-0001-4714-3434
SPIN-code: 4933-4507

MD, Cand. Sci. (Pharmaceuticals)

Russian Federation, Saint Petersburg

Elena S. Smirnova

Military Medical Academy

Email: vmeda-nio@mail.ru
ORCID iD: 0009-0009-4820-4313
SPIN-code: 9290-4277

MD, Cand. Sci. (Pharmaceuticals)

Russian Federation, Saint Petersburg

References

  1. Dalke IV, Zakhozhiy IG, Chadin IF. Distribution of Heracleum sosnowskyi on the territory of the Syktyvkar city (Komi Republic, Russia) and management of the invasion by the city administration. Bulletin of the Institute of Biology of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences. 2018;3(205):2–13. (In Russ.) doi: 10.31140/j.vestnikib.2018.3(205).1
  2. Bogdanov VL, Nikolaev RV, Shmeleva IV. Invasion of an ecologically dangerous plant, Sosnowsky’s hogweed (Heracleum sosnowskyi Manden.), on the territory of the European part of Russia. Regional’naya Ecologiya. 2011;(1–2(31)):43–52. (In Russ.) EDN: TWHUIN
  3. Arepieva LA, Arepiev EI, Kazakov SG. Distribution of Sosnovsky’s hogweed (Heracleum Sosnowskyi) on the southern border of the secondary range in the European part of Russia. Russian Journal of Biological Invasions. 2021;14(2):2–15. (In Russ.) EDN: SUGZHG doi: 10.35885/1996-1499-2021-14-2-2-15
  4. Kurenkova EM, Starodubtseva AM. Heracleum L. species in hayfields and pastures of the forest zone in European Russia. Fodder Journal. 2018;(5):15–26. (In Russ.) EDN: XOAMQP doi: 10.25685/KRM.2018.2018.13026
  5. Ozerova NA, Krivosheina MG. Patterns of secondary range formation for Heracleum Sosnowskyi and H. mantegazzianum on the territory of Russia. Russian Journal of Biological Invasions. 2018;11(1):78–87. (In Russ.) EDN: YSIMFP
  6. Luneva NN. Heracleum Sosnowsky in the Russian Federation. Protection and quarantine of plants. 2014;(3):12–18. (In Russ.) EDN: RYEMSJ
  7. Abramova LM, Golovanov YaM, Rogozhnikova DR. Sosnovsky hogweed (Heracleum Sosnovskyi Manden., Apiaceae) in Bashkortostan // Russian Journal of Biological Invasions. 2021;14(1):2–12. (In Russ.) EDN: WYZLLX doi: 10.35885/1996-1499-2021-14-1-2-12
  8. Satsyperova IF. Hogweeds of the USSR flora are new forage plants. Leningrad: Nauka Publ.; 1984. 223 p. (In Russ.) EDN: YLDSSY
  9. Ozerova NA, Shirokova VA, Krivosheina MG, Petrosyan VG. The spatial distribution of Sosnowsky’s hogweed (Heracleum sosnowskyi) in the valleys of big and medium rivers of the East-European Plain (on materials of field studies 2008–2016). Russian Journal of Biological Invasions. 2017;10(3):38–63. (In Russ.) EDN: ZEHBPR
  10. Myshlyakov SG, Artemova AI. Mapping the habitats of Sosnovsky’s hogweed using Sentinel 2 satellite images. In: Modern problems of remote sensing of the Earth from space. Fifteenth All-Russian open conference, November 13–17. Moscow; 2017:380. (In Russ.) EDN: YXGGBB
  11. Ebel’ AL, Zykova EYu, Mikhailova SI, et al. Dispersal and naturalization of the invasive species Heracleum sosnowskyi Manden. (Apiaceae) in Siberia. In: Ecology and geography of plants and plant communities. Materials of the IV International Scientific Conference, April 16–19. 2018; Ekaterinburg:1065–1070. (In Russ.) EDN: XUUPVR
  12. Antipina GS, Platonova EA. Invasive species Lupinus polyphyllus Lindl. and Heracleum sosnowskyi Manden. in the Botanical Garden of Petrozavodsk University. Scientific Notes of the “Cape Martyan” Nature Reserve. 2022;(13):79–88. (In Russ.) EDN: ZISDCM doi: 10.36305/2413-3019-2022-13-79-88
  13. Shumovskaya DA. Experience in the study and use of Sosnowskyi hogweed (Heracleum sosnowskyi Manden.) in the Russian Federation, Belarus, Kazakhstan, Lithuania, Latvia, Estonia and Poland. Problems of the environment and natural resources. 2023;(4):126–139. (In Russ.) EDN: ADAUUH doi: 10.36535/0235-5019-2023-04-2
  14. Afonin AN, Luneva NN, Li YuS, Kotsareva NV. Ecological-geographical analysis of distribution pattern and occurrence of cow-parsnip (Heracleum sosnowsky Manden) with respect to area aridity and its mapping in European Russia. Russian Journal of Ecology. 2017;(1):66–69. (In Russ.) EDN: XHMOYT doi: 10.7868/S0367059717010036
  15. Luneva NN, Konechnaya GYu, Smekalova TN, Chukhina IG. On status of Heracleum sosnowskyi Manden. on the territory of Russian Federation. Bulletin of plant protection. 2018;(3(97)):10–15. (In Russ.) EDN: VJWTIN doi: 10.31993/2308-6459-2018-3(97)-10-15
  16. Andreeva LV. Hogweed as a source of environmental problems. In: Fundamental and applied research in priority areas of bioecology and biotechnology. Materials of the V All-Russian Scientific and Practical Conference with International Participation, May 20. Ulyanovsk; 2022:8–10.(In Russ.) EDN: EAWGPE
  17. Sadovnikova TP, Ul’yankina TD, Snakin VV. Dangerous introduce: the Heracleum sosnowskyi Manden. Use and protection of natural resources in Russia. 2018;(3(155)):61–65. (In Russ.) EDN: YZRBIL
  18. Ozerova NA. Vectors of Heracleum sosnowskyi Manden. Invasion on the territory of Moscow region: history and modernity (as exemplified by the Shakhovskaya Urban District). In: IOP Conference Series: Earth and Environmental Science. T. 867. Moscow, 2021:012074. EDN: UULDNQ doi: 10.1088/1755-1315/867/1/012074
  19. Patent RUS2706552C1/19.11.2019. Byul. N 32. Petrova IV, Osminin AG, Yusupov IA, et al. Method for destroying Sosnovsky’s hogweed. (In Russ.) Available from: https://patenton.ru/patent/RU2706552C1 (date of access: 04.06.2023).
  20. Patent RUS2750754C2/02.07.2021. Byul. N 19. Shapovalov DA, Ozerova NA, Krivosheina MG, et al. A method of protecting lands from the spread of Sosnovsky’s hogweed. (In Russ.) Available from: https://patenton.ru/patent/RU2750754C2 (date of access: 03.05.2023).
  21. Patent RUS2683517C1/28.03.2019. Byul. N 10. Egorov AB, Pavlyuchenkova LN. Method for destroying hogweed. (In Russ.) Access mode: https://yandex.ru/patents/doc/RU2683517C1_20190328 (date of access: 08.05.2023).
  22. Simonova AYu, Belova MV, Ilyashenko KK, et al. Photochemical dermatitis due to contact with Sosnovsky hogweed. Sklifosovsky Journal Emergency Medical Care. 2020;9(4):653–658. (In Russ.) EDN: LPLNXJ doi: 10.23934/2223-9022-2020-9-4-653-658
  23. Simonova AYu, Ilyashenko KK, Pidchenko NE, Potskhveria MM. Photochemical dermatitis as a result of contact with the juice of Sosnovsky’s hogweed. Moskovskaya meditsina. 2019;(6(34)):91. (In Russ.) EDN: AFIXAF
  24. Tamrazova OB, Seleznev SP, Tamrazova AV. Phytodermatitis in children caused by the Sosnovski hogweed. Pediatriya. Consilium Medicum. 2019;(2):53–57. (In Russ.) EDN: KIMQWI doi: 10.26442/26586630.2019.2.190418
  25. Sheplyakova VE. Group composition of lipid compounds and free acids of leaves of Sosnovsky hogweed in autumn and summer. In: Problems and prospects for sustainable development of industry in the 21st century: from theory to practice. Student conference, April 21. Saint Petersburg; 2022:151–154. (In Russ.) EDN: YXUYDW
  26. Tkachenko KG. Genus Heracleum L. — prospective essential oil plants. In: Scientific and innovative potential for the development of production, processing and use of essential oil and medicinal plants. International scientific and practical conference, June 13–14. Simferopol’; 2019:88–92. (In Russ.) EDN: AOPOLT
  27. Kireeva NE, Shekhovtsova AYu, Kuvardin NV. Methods of preparation for the use of Sosnovsky’s hogweed in medicinal plant raw materials. In: Generation of the Future: View of Young Scientists-2020. Ninth International Youth Scientific Conference, November 12–13. Kursk; 2020:111–113. (In Russ.) EDN: MQAJZL
  28. Khodzimatov M, Navruzshoeva G. Heracleum lehmannianum bunge — plant with aromatics oil. Izvestiya Akademii nauk Respubliki Tadzhikistan. Otdeleniye biologicheskikh i meditsinskikh nauk. 2007;(1):28–31. (In Russ.) EDN: ZOLNRH
  29. Tkachenko KG. Essential oils and systematics of the genus Heracleum L. Turczaninowia. 2010;13(4):74–87. (In Russ.) EDN: MWKRRV
  30. Orlin NA. On the extraction of coumarins from hogweed. Advances in current natural sciences. 2010;(3):13–14. (In Russ.) EDN: KYRHQF
  31. Stefanachi A, Leonetti F, Pisani L, et al. Coumarin: A naturale, privileged and versatile scaffold for bioactive compounds. Molecules. 2018;23(2):250. doi: 10.3390/molecules23020250
  32. Chernyak DM. Sosnowsky’s hogweed (Heracleum Sosnowskyi Manden.) and Moellendorf’s hogweed (Heracleum Moellendoffii Hance) in the south of Primorsky Krai (biological features, prospects for use and biological activity): [dissertation]. Vladivostok; 2013. Available from: https://www.dissercat.com/content/borshchevik-sosnovskogo-heracleum-sosnowskyi-manden-i-borshchevik-mellendorfa-heracleum-moel (access date: 04.05.2023). (In Russ.)
  33. Grzędzicka E. Invasion of the Giant Hogweed and the Sosnowsky’s Hogweed as a Multidisciplinary Problem with Unknown Future — A Review. Earth. 2022;3(1):287–312. doi: 10.3390/earth3010018
  34. Khodzimatov M, Navruzshoeva G. Cumarian Heracleum lehmannianum Bunge fruits. Reports of the National Academy of Sciences of Tajikistan. 2008;51(7):549–553. (In Russ.) EDN: OUWFSF
  35. Andreeva LV. Dependence of the coumarin content in the Sosnovsky hogweed on the region of its growth. In: Modern approaches to the development of agro-industrial, chemical and forestry complexes. Problems, trends, prospects. All-Russian scientific and practical conference, March 17. Veliky Novgorod; 2021:155–159. (In Russ.) EDN: VSIHPR
  36. Jakubowicz O, Źaba C, Nowak G, et al. Heracleum sosnowskyi Manden. Ann Agric Environ Med. 2012;19(2):327–328. PMID: 22742809
  37. Politowicz J., Gębarowska E., Prockow J., et al. Antimicrobial activity of essential oil and furanocoumarin fraction of three Heracleum species. Acta Pol Pharm. 2017;74(2):723–728. PMID: 29624280
  38. Bruno R, Barreca D, Protti M, et al. Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest. Molecules. 2019;24(11):2163. doi: 10.3390/molecules24112163
  39. Ozek G, Yur S, Goger F, et al. Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum extracts against enzymes involved in alzheimer’s disease and type II diabetes. Chemistry & Biodiversity. 2019;16(4):1–25. doi: 10.1002/cbdv.201800672
  40. Bahadori MB, Dinparast L, Zengin G. The Genus Heracleum: A comprehensive review on its phytochemistry, pharmacology, and ethnobotanical values as a useful herb. Compr Rev Food Sci Food Saf. 2016;15(6):1018–1039. doi: 10.1111/1541-4337.12222
  41. Lozhkin A, Sakanyan EI. Natural coumarins: methods of extraction. Pharmaceutical Chemical Journal. 2006;40(6):47–56. (In Russ.) EDN: TALJMN doi: 10.30906/0023-1134-2006-40-6-47-56
  42. Laman NA, Usik AW. Localization and composition of coumarins in roots of Heracleum Sosnowskyi Manden. Proceedings of the National Academy of Sciences of Belarus. Biological Series. 2020;65(1):71–75. (In Russ.) EDN: TRRPTP doi: 10.29235/1029-8940-2020-65-1-71-75
  43. Kozlova GG, Pikhtovnikov SV, Belousova KA, Latipova LF. Extraction of coumarins from natural sources for use in the synthesis of complexes of lanthanides. Bulletin of Science and Practice. 2016;(6):31–34. (In Russ.) EDN: WBDUXF doi: 10.5281/zenodo.55870
  44. Punegov VV, Gruzdev IV, Triandafilov AF. Analysis of the composition of lipophilic substances in Heracleum Sosnowskyi juice before and after electric discharge cavitation treatment. Khimija Rastitel’nogo Syr’ja. 2019;(3):61–68. (In Russ.) EDN: ZFUKPE doi: 10.14258/jcprm.2019034253
  45. Tiley GE, Dodd FS, Wade PM. Heracleum mantegazzianum Sommier & Levier. Journal of Ecology. 1996;84(2):297–319. doi: 10.2307/2261365
  46. Patocka J, Cupalova K. Giant Hogweed and photodermatitis. Mil Med Sci Lett (Voj Zdrav Listy). 2017;86(3):135–138. doi: 10.31482/mmsl.2017.021
  47. Karimian-Teherani D, Kinaciyan T, Tanew A. Photoallergic contact dermatitis to Heracleum giganteum. Photodermatol Photoimmunol Photomed. 2008;24(2):99–101. doi: 10.1111/j.1600-0781.2008.00346.x
  48. Kasperkiewicz K, Erkiert-Polguj A, Budzisz E. Sunscreening and photosensitizing properties of coumarins and their derivatives. Lett Drug Des Discov. 2016;13(5):465–474. doi: 10.2174/1570180812666150901222106
  49. Nevozinskaya ZA, Potekaev NN, Korsunskaya IM, et al. Photophytodermatitis. Klinicheskaya Dermatologiya i Venerologiya. 2014;12(3):72–76. (In Russ.) EDN: SUDQPH
  50. Muzykiewicz A, Nowak A, Klimowicz A, Florkowska KM. Fotoalergeny i zwiazki fototoksyczne pochodzenia roślinnego. Zagrożenia i korzyści terapeutyczne. Kosmos. Problemy naul biologicznych. 2017;66(2):207–216. (In Polish)
  51. Vons BV, Chubka MB, Groshovyi TA. The problem of treatment of burns’ wounds and characteristic of drugs for the local treatment of burns. Current issues in pharmacy and medicine: science and practice. 2018;11(1):119–125. (In Ukrainian) EDN: YTXQWY doi: 10.14739/2409-2932.2018.1.123731
  52. Jermendy G, Visolyi G. Phytophotodermatitis bullosa in an elderly patient. Advances in Dermatology and Allergology. 2022;39(3): 611–612. doi: 10.5114/ada.2022.117538
  53. Flanagan KE, Blankenship K, Houk L. Botanical briefs: Phytophotodermatitis caused by giant Hogweed (Heracleum mantegazzianum). Cutis. 2021;108(5):251–253. doi: 10.12788/cutis.0389

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2. Fig. 1. Structure of orthocoumaric acid (1) and coumarin (2)

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3. Fig. 2. Structure of furanocoumarins: psoralen (1), angelicin (2), allopsoralen (3), 3,4-furocoumarin (4)

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