DEVELOPMENT OF THE APPROACH OF MULTICOMPONENT SOLID DOSAGE FORMS’S IDENTIFICATION BY MEANS OF RAMAN SPECTROSCOPY EXEMPLIFIED BY “PANADOL” SOLUBLE TABLETS

Raman spectroscopy is an express non-destructive physicochemical method of analysis which has an application as an analytical tool is possible in the pharmaceutical and related fields. The current state pharmacopoeias of the Russian Federation (XIV edition), Belarus (2 edition), Ukraine (2 edition), USA (USP 38), the European Pharmacopoeia (9.8 edition) include general pharmacopeial monographs describing the possibilities of Raman spectroscopy in relation to drugs’ identification and quantification. However, nowadays there is only one pharmacopeial monograph describing the application of Raman spectroscopy as a method for controlling the completeness of the Dissolution test. Taking into account such capabilities of the method as the analysis of small quantities of the test object without preliminary preparation of the test object and obtaining spectral information from the far-infrared region that is impossible with other available pharmacopeial methods the study was carried out aiming to develop an approach for analyzing the composition of complex solid dosage forms. The approach for identifying some solid multicomponent dosage forms by Raman spectroscopy using visual interpretation of spectral data have been developed exemplified by model mixtures proportionally reproducing the composition of the soluble Panadol tablets, both completely and in combination with the main component of paracetamol with each of the excipients, The developed approach has been established to be a useful technique for reliable determination of the combination of substances’ presence in the model mixture by the characteristic features of the spectral picture and hybrid signals. Also, developed approach let to establish the presence of minor components in the composition of the sample.

identification, multicomponent mixtures, paracetamol, Raman spectroscopy, tablets