Email this article 
Post a Comment MODERN POLICY OF CANCER IN PREGNANCY TO OVERCOME A HARDSHIP
- Authors: Kedrova AG1, Levakov SA1
-
Affiliations:
- ФГБОУ ДПО «Институт повышения квалификации» ФМБА России
- Issue: Vol 5, No 3 (2014)
- Pages: 43-50
- Section: Articles
- URL: https://journal-vniispk.ru/clinpractice/article/view/8298
- DOI: https://doi.org/10.17816/clinpract5343-50
- ID: 8298
Cite item
Full Text
Abstract
The natural tissue remodeling that occurs in reproductive organs of women following pregnancy and lactation promotes cancer progression, accounting for 'the dual effect' of pregnancy. There are the tumor promoting activity of physiologic regression is due to an inflammation-like microenvironment that is present during reproductive organs regression. The hypothesis that hormone-stroma from an actively involuting reproductive organs promotes tumor progression is being evaluated using both in vivo and in vitro model systems. ECM proteins that activate tumor cells invasion are being identified using proteomic approaches. We have carried out our analysis of 16 patients with pregnancy-associated cancer. The most common cases of cancer were: cervical cancer, breast cancer, ovarian cancer and lymphoproliferative disorders. In each case, the decision about the tactics of pregnancy and treatment of cancer were taken individually together with oncologists, obstetricians, pediatricians and patients. The difficulties for the adoption of an optimal solution can be attributed insufficient evidentiary basis for tactical decisions, which are often the main cause of health in favor of abortion, although the woman, in almost all cases was strongly tuned to its prolongation. Our analysis also showed a low awareness of physicians about this issue, the need for its wider discussion, both among health professionals and women who have to get up on the pregnancy as soon as possible and be tested in compliance with the principles of oncological alertness.
Keywords
About the authors
A G Kedrova
ФГБОУ ДПО «Институт повышения квалификации» ФМБА России
Email: kedrova.anna@gmail.com
профессор кафедры акушерства и гинекологии ФГБОУ ДПО ИПК ФМБА России, д.м.н.
S A Levakov
ФГБОУ ДПО «Институт повышения квалификации» ФМБА Россиизав. кафедрой акушерства и гинекологии ФГБОУ ДПО ИПК ФМБА России, д.м.н., проф.
References
- Morice P, Uzan C, Gouy S, et al. Gynaecological cancers in pregnancy. The Lancet. 2012; 379(9815): 558 - 69.
- Рошаль Л.М. Президент Национальной медицинской палаты, Директор НИИ неотложной детской хирургии и травматологии. Интервью http://www.pravmir.ru/leonid-roshal-mizdrav/ май 2012.
- Campion M.J., Sedlacek T.V. Colposcopy in pregnancy. Obstet Gynecol Clin North Am 1993; 20(1):153-63.
- Apgar BS, Kittendorf AL, Bettcher CM, Wong J, Kaufman AJ. Update on ASCCP consensus guidelines for abnormal cervical screening: tests and cervical histology. Am Fam Physician. 2009; 80:147-55.
- Fukushima K; Ogawa S; Tsukimori K. Can we diagnose invasive cervical cancer during pregnancy as precise as in nonpregnant women?: maternal and perinatal outcome in pregnancies complicated with cervical cancers. Int J Gynecol Cancer. 2009; 19(8):1439-45 (ISSN: 1525-1438).
- Morice P., Uzan С., Verschraegen С, Gouy S, Haie-Meder С. Gynaecological cancers in pregnancy. The Lancet, 2012; 379 (9815): 558 - 69.
- Bader AA, Petru E, Winter R. Long-term follow-up after neoadjuvant chemotherapy for high-risk cervical cancer during pregnancy. Gynecol Oncol. 2007; 105(1):269-72.
- Plante M, Gregoire J, Renaud MС, Roy M. The vaginal radical trachelectomy: An update of a series of 125 cases and 106 pregnancies. Gynecol Oncol. 2011;121(2):290-97.
- Son HK, Kam S, Park KS. The factors associated with changes in the stage of breast cancer screening behavior among the women who are eligible for the Korean National Cancer Screening Program. J Prev Med Public Health. 2009; 42(2): 109-16.
- Chen T, Lukanova A, Grankvist K, et al. IGF-I during primiparous pregnancy and maternal risk of breast cancer. Breast Cancer Res Treat. 2010; 121(1):169-75.
- Cardonick E, Dougherty R, Grana G, et al. Breast cancer during pregnancy: maternal and fetal outcomes. Cancer J. 2010; 16(1):76-82.
- Параконная А.А. Рак молочной железы и беременность. Автореф. дис.. докт. мед. наук, Москва, РОНЦ им. Н.Н. Блохина РАМН, 2009.
- Largillier R, Savignoni A, Gligorov J, et al. Prognostic role of pregnancy occurring before or after treatment of early breast cancer patients aged №35 years: a GET(N)A Working Group analysis. Cancer. 2009; 115(22):5155-65.
- Greve T; Madison V. In vitro fertilization in cattle: a review. Reprod Nutr Dev. 1991; 31(2): 147-57.
- Matsunoki A, Yoshino H, Takayanagi T, et al. Breast cancer during pregnancy - a case report. Gan To Kagaku Ryoho. 2008; 35(6):991-3. (ISSN: 0385-0684).
- Kirby T. FrJdJric Amant: leading the agenda on cancer in pregnancy. Lancet. 2012; 379 (9815): 511.
- Robova H, Rob L, Hrehorcak M. Tumor of epidermal sinus during pregnancy. Int J Gynecol cancer. 2007; 17 (4): 914-6.
- Koo YJ, Lee JE, Lim KT, et al. A 10-year experience of laparoscopic surgery for adnexal masses during pregnancy. Int J Gynecol Obstet. 2011; 113 (1): 36-9.
- Brener B., Avivi I., Lishner M. Haematological cancers in pregnancy. Lancet. 2012; 379 (9815): 580-7.
- Kehoe S. Cervical and endometrial cancer during pregnancy. Recent Results Cancer Res. 2008; 178: 69-74.
- Hannuna KY, Putignani L, Silvestry E, et al. Incidental endometrial adenocarcinoma in early pregnancy: a case report and review of the literature.Int J Gynecol Cancer. 2009; 19(9):1580-4.
- Amant F, Van Calsteren K, Debiec-Rychter M, et al. High-grade endometrial stromal sarcoma presenting in a 28-year-old woman during pregnancy: a case report. J Med Case Rep. 2010; 4:243.
- Kalogiannidis I, Agorastos T. Conservative management of young patients with endometrial highly-differentiated adenocarcinoma. J Obstet Gynaecol. 2011; 31(1):13-7.
- Cardonick E, Dougherty R, Grana G, et al. Breast cancer during pregnancy: maternal and fetal outcomes. Cancer J. 2010; 16(1):76-82.
Supplementary files
