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Post a Comment Theoretical analysis of the predictability indices of the binary genetic tests
- Authors: Rubanovich A.V.1, Khromov-Borisov N.N.2
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Affiliations:
- Vavilov Institute of General Genetics RAS
- Saint-Petersburg State I. P. Pavlov Medical University
- Issue: Vol 11, No 1 (2013)
- Pages: 77-90
- Section: Articles
- URL: https://journal-vniispk.ru/ecolgenet/article/view/2398
- DOI: https://doi.org/10.17816/ecogen11177-90
- ID: 2398
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Abstract
A set of formulas for the indices of performance and predictive ability of the binary genetic tests is presented. Their dependence on disease prevalence and population frequency of a genetic marker is characterized. It is shown that a marker with the odds ratio OR < 2.2 has an initially low prognostic efficiency in every sense and at any frequencies of the disease and the marker. A marker can be a good classifier, when OR > 5.4, but only when its population frequency is rather high (>0.3). The formulas are presented that allow to obtain indirect estimates of absolute and relative risk of the disease for the carrier of a marker in the case-control studies
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##article.viewOnOriginalSite##About the authors
Aleksandr Vladimirovich Rubanovich
Vavilov Institute of General Genetics RAS
Email: rubanovich@vigg.ru
Head of Lab of ecological genetic
Nikita Nikolayevich Khromov-Borisov
Saint-Petersburg State I. P. Pavlov Medical University
Email: Nikita.KhromovBorisov@gmail.com
ssociate professor, Department of Physics, Mathematics and Informatics
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