Optimal drugs concentrations and doses for allergological diagnostics of perioperative drugs hypersensitivity reactions
- Authors: Zhukova DG1, Fedenko ES2, Yudin AA1,3
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Affiliations:
- Central clinical hospital of the Russian Academy of sciences
- Institute of Immunology
- Pirogov Russian National Research Medical university
- Issue: Vol 12, No 1 (2015)
- Pages: 27-33
- Section: Articles
- URL: https://journal-vniispk.ru/raj/article/view/120801
- DOI: https://doi.org/10.36691/RJA475
- ID: 120801
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Abstract
Background. The study aimed to develop the optimal concentration and doses of drugs for examination of perioperative drug’s hypersensitivity reactions. Methods. The protocol of allergological examination included clinical, laboratory methods and tests in vivo: skin tests (prick-, intradermal, patch- test) with neuromuscular blockers, opioids, radiocontrast medias, colloids, hypnotics; patch-test with povidon-iodine, chlorhexidine; dosing provocative test (including investigation of blood, nasal secretion eosinophilia, serum tryptase measurements) with antibiotics, nonsteroid anti-inflammatory drugs, local anesthetics. 20 healthy volunteers were included in the study during 2 years (2010-2012) for estimating of the doses and concentrations of testing drugs. Results. Non irritating concentrations for skin tests (prick- and intradermal) with perioperative drugs have been estimated on healthy controls. No one of healthy controls had false positive tests and nonspecific histamine-release effects while testing in vivo. Increased tryptase level 1 h after and the level of blood eosinophilia and eosinophiliaof nasal secretion 6 hours after dosing provocation test with each drug were found to be statistically insignificant. Conclusions. Optimal concentrations and doses of drugs for allergological examination of perioperative drug’s hypersensitivity reactions were estimated.
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##article.viewOnOriginalSite##About the authors
D G Zhukova
Central clinical hospital of the Russian Academy of sciences
Email: zulyaevan@mail.ru
г. Москва
E S Fedenko
Institute of Immunologyг. Москва
A A Yudin
Central clinical hospital of the Russian Academy of sciences; Pirogov Russian National Research Medical universityг. Москва
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