Dynamics of clinical symptoms and immunity local parametres during allergen - specific immunotherapy in patents with pollinosis and combined forms of sensibilization
- Authors: Bezrukova EV1, Molotilov BA1
-
Affiliations:
- Regional clinical Hospital of Penza, Penza Institute of Post graduate education
- Issue: Vol 7, No 3 (2010)
- Pages: 14-18
- Section: Articles
- URL: https://journal-vniispk.ru/raj/article/view/121350
- DOI: https://doi.org/10.36691/RJA873
- ID: 121350
Cite item
Open Access
Access granted
Subscription Access
Abstract
Background. To evaluate clinical and immunological efficiency of immunotherapy of pollinosis patients with
combined forms of sensitization with «Sevapharma» allergens, Czech Republic.
Materials and methods. 189 patients with pollinosis (age 18-55 years old) were examined during this study. Out
of these 189 patients three groups were chosen to be treated with pollen allergens made in Czech Republic and
domestic allergens from Russia. During the study slgA in saliva was examined and the efficiency of different
AS IT methods with combined forms of sensitization was tested.
Results. Patients with pollinosis had disruption in local immunity. slASIT increases slgA production in saliva.
Treatment with interfacing allergens is most effective in combined forms of sensitization.
Conclusion. The sensibilization to different kinds of pollen allergens was observed in 10- 15% of cases. Combined
forms of sensitization are much more common. Moreover, combined forms of sensitization to pollen and domestic
allergens predominate. Besides that, the study showed pollinosis patients have disruption of local immunity that
appeared in slgA deficit in oral cavity. Sublingual immunotherapy is the most effective method of treatment. In
case of combined forms of sensitization treatment with interfacing allergens is the most efficient.
combined forms of sensitization with «Sevapharma» allergens, Czech Republic.
Materials and methods. 189 patients with pollinosis (age 18-55 years old) were examined during this study. Out
of these 189 patients three groups were chosen to be treated with pollen allergens made in Czech Republic and
domestic allergens from Russia. During the study slgA in saliva was examined and the efficiency of different
AS IT methods with combined forms of sensitization was tested.
Results. Patients with pollinosis had disruption in local immunity. slASIT increases slgA production in saliva.
Treatment with interfacing allergens is most effective in combined forms of sensitization.
Conclusion. The sensibilization to different kinds of pollen allergens was observed in 10- 15% of cases. Combined
forms of sensitization are much more common. Moreover, combined forms of sensitization to pollen and domestic
allergens predominate. Besides that, the study showed pollinosis patients have disruption of local immunity that
appeared in slgA deficit in oral cavity. Sublingual immunotherapy is the most effective method of treatment. In
case of combined forms of sensitization treatment with interfacing allergens is the most efficient.
About the authors
E V Bezrukova
Regional clinical Hospital of Penza, Penza Institute of Post graduate education
Email: giuv@sura.ru
Regional clinical Hospital of Penza, Penza Institute of Post graduate education
B A Molotilov
Regional clinical Hospital of Penza, Penza Institute of Post graduate educationRegional clinical Hospital of Penza, Penza Institute of Post graduate education
References
- Манжос М.В., Шкадов С.А., Никишин А.В. и соавт. Определение антител в слюне больных поллинозом методом иммуноферментного анализа. Биотехнология.2006, № 4, с. 93-95.
- Akdis М., Verhagen J., Taylor A. et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med, 2004, v. 199, p. 1567-1575.
- Akdis M., Schmidt-Weber C, Jutel M., Akdis C.A., Blaser K. Mechanisms of allergen immunotherapy. Allergy Clin Immunol Int. J. World Allergy Org. 2004, v. 16, No. 2, p. 65-69.
- Mailing H.J. Is sublingual immunotherapy clinically effective? Allergy Clin. Immunol. 2002, v. 2, No. 6, p. 523-531.
- Marogna M., Massolo A. Sublingual immunotherapy in the context of a clinical practice improvement program in the allergological setting: results of along-term observational study. Allerg Immunol. (Paris). 2003, v. 35, No. 4, p. 133-140.
- Marogna M., Spadolini I., Massolo A. et al. Randomized controlled open study of Sublingual immunotherapy for respiratory allergy in real life: clinical efficacy and more. Allergy. 2004, v. 59, No. 11, p. 1205-1210.
- RienzoV.D., MarcucciE, PuccinelliP. etal. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study. Clin. Exp. Allergy. 2003, v. 33, No. 2, p. 206-210.
- Балаболкин И.И. Распространенность, диагностика и лечение поллинозаудетей. Аллергология. 1998, № 2, с. 41-45.
- Хаитов P.M., Богова А.В., Ильина Н.И. Эпидемиология аллергических заболеваний в России. Иммунология. 1998, № 3, с. 4-9.
- Баранов А А., Хаитов P.M., Чучалин А.Е и соавт. Аллергический ринит и его влияние на астму (ARIA 2008). Возможность использования в России новой версии документа. Рос. Аллергол. Журн. 2008, № 5, с. 3-8.
- Манжос М.В., Рыжкин Д.В., ЖелтиковаТ.М. Особенности течения поллиноза и аэропалинологическая характеристика в г. Пензе. Аллергология. 2004, № 2, с. 29-33.
- Порошина ЮА., Полсачева О.В., Передкова Е.В. Ускоренный метод специфической иммунотерапии поллинозов. Методические рекомендации. М., 1988, 12 с.
- Атовмян О.И., Герман Т.П., Чернохвостова Е.В. Сывороточные и секреторные иммуноглобулины при аллергических заболеваниях. ЖМЭИ. 1985, № 7, с. 88-94.
Supplementary files
