Metabolic engineering of Escherichia coli for L-tryptophan production


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Abstract

The review summarizes the main approaches applied during the creation of L-tryptophan producing strains based on Escherichia coli for the industrial production of this amino acid. In addition, some prospects for the further improvement of tryptophan producers to increase their productivity and improve their technological characteristics based on systems metabolic engineering approaches are outlined in the review. These approaches can be used to obtain the producers of other aromatic amino acids and tryptophan precursors or derivatives.

About the authors

V. B. Panichkin

Ajinomoto-Genetika Research Institute (AGRI)

Author for correspondence.
Email: vladimir_panichkin@agri.ru
Russian Federation, Moscow, 117545

V. A. Livshits

Ajinomoto-Genetika Research Institute (AGRI)

Email: vladimir_panichkin@agri.ru
Russian Federation, Moscow, 117545

I. V. Biryukova

Ajinomoto-Genetika Research Institute (AGRI)

Email: vladimir_panichkin@agri.ru
Russian Federation, Moscow, 117545

S. V. Mashko

Ajinomoto-Genetika Research Institute (AGRI)

Email: vladimir_panichkin@agri.ru
Russian Federation, Moscow, 117545

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