Metabolic engineering of Escherichia coli for L-tryptophan production
- Authors: Panichkin V.B.1, Livshits V.A.1, Biryukova I.V.1, Mashko S.V.1
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Affiliations:
- Ajinomoto-Genetika Research Institute (AGRI)
- Issue: Vol 52, No 9 (2016)
- Pages: 783-809
- Section: Problems, Prospects
- URL: https://journal-vniispk.ru/0003-6838/article/view/152125
- DOI: https://doi.org/10.1134/S0003683816090052
- ID: 152125
Cite item
Abstract
The review summarizes the main approaches applied during the creation of L-tryptophan producing strains based on Escherichia coli for the industrial production of this amino acid. In addition, some prospects for the further improvement of tryptophan producers to increase their productivity and improve their technological characteristics based on systems metabolic engineering approaches are outlined in the review. These approaches can be used to obtain the producers of other aromatic amino acids and tryptophan precursors or derivatives.
About the authors
V. B. Panichkin
Ajinomoto-Genetika Research Institute (AGRI)
Author for correspondence.
Email: vladimir_panichkin@agri.ru
Russian Federation, Moscow, 117545
V. A. Livshits
Ajinomoto-Genetika Research Institute (AGRI)
Email: vladimir_panichkin@agri.ru
Russian Federation, Moscow, 117545
I. V. Biryukova
Ajinomoto-Genetika Research Institute (AGRI)
Email: vladimir_panichkin@agri.ru
Russian Federation, Moscow, 117545
S. V. Mashko
Ajinomoto-Genetika Research Institute (AGRI)
Email: vladimir_panichkin@agri.ru
Russian Federation, Moscow, 117545
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