


Vol 51, No 5 (2018)
- Year: 2018
- Articles: 17
- URL: https://journal-vniispk.ru/0006-3398/issue/view/14624
Theory and Design
Use of Ion Beam Modification and Gas-Thermal Oxidation in the Process of Formation of Structurally Heterogeneous Oxide Coatings for Titanium Medical Implants
Abstract
A new promising method for preliminary ion beam processing of titanium implants has been suggested and tested. The method uses high-energy Не+ ion implantation to achieve a high level of open porosity needed to form thin-layered coatings by the method of gas-thermal oxidation in air. The mechanism of pore formation and the effect of the obtained structurally heterogeneous oxide coatings on the osteointegration of rod implants are described.



Article
An Optoacoustic Laser Cytometer Prototype
Abstract
The optoacoustic effect leading to excitation of acoustic waves upon absorption of a variable light flux is considered. This effect is of interest from the viewpoint of practical application in biomedical measurements as a promising noninvasive method for diagnostics of biological objects. The results of experimental flow diagnostics based on laser excitation of an optoacoustic signal in liquid are presented. An algorithm of the flow cytometry procedure is developed.



A Model Medicinal Contact Lens Containing Opaque Medicinal Formulations
Abstract
Features of the construction and the main characteristics of an original model of a medicinal soft contact lens are described. Results from studies of the properties of these lenses are presented. The potential for using this original soft contact lens in clinical ophthalmology is evaluated.



Development of Laminated Thermoelectric Modules for a Neonatal Resuscitation System
Abstract
Computation of the temperature regime of a thermoelectric neonatology system is considered. Differential equations are used to provide the basis for computational relationships describing convective heat exchange in the system. Laminated thermoelectric batteries are calculated and optimized to form a specified distribution of temperatures in the neonatology resuscitation system. The optimized characteristics of the laminated thermal element are presented.



An Experimental Study of Thermal Characteristics of Minimally Invasive Cryoprobes in Different Cooling Modes
Abstract
The use of special software for planning and monitoring cryosurgical operations is one of the main ways to improve the efficiency of cryosurgery. To develop such software, it is necessary to have detailed data on the temperature characteristics of cryoprobes. In this work, time dependences of temperature distributions along the working parts of cryoprobes have been experimentally obtained for two types of minimally invasive cryoprobes in different operation modes (continuous coolant feeding with 100% cooling capacity; pulsed feeding with 20, 40, 60, 80% cooling capacity). The obtained results can be used in computer modeling of multi-probe cryosurgical operations with the use of serially produced cryoprobes and for evaluating the efficiency of the cryoprobes being developed.






Determination of Heart Rate Variability from High-Resolution Esophageal Manometry Data
Abstract
The article considers the possibility of calculating heart rate variability from heart rate data obtained by filtering high-resolution esophageal manometry signals. The data from a single sensor in the central region of the esophagus were used so that the effect of cardiac activity on the signal was most pronounced. After filtering, a sinusoidal signal was obtained. This signal was processed using a peak detector to calculate the time distance between the extrema. Based on manometry and ECG data, histograms and scattergrams were constructed and the variability parameters were calculated.



Comparative Assessment of Variability in Parameters of the Conventional and Averaged ECG
Abstract
We present here a method for computerized processing of electrocardiograms providing for averaging of the electrocardiogram signals over prolonged periods. The results of a comparative evaluation of the variability of the amplitude and time parameters of conventional and averaged electrocardiography are presented. Averaged electrocardiography is shown to have advantages over conventional methods of processing the electrocardiogram signals for personalized monitoring of electrocardiographic changes due to its higher reproducibility.



Noninvasive Determination of Blood Glucose Concentration by Comparing the Eardrum and Head Skin Temperatures
Abstract
A noninvasive method for determination of blood glucose concentration from the eardrum and head skin temperatures was suggested and tested. The method takes into account the effects of food intake and ambient temperature on blood glucose concentration. The method successfully underwent tests in healthy subjects and patients with diabetes mellitus.



Getting Daily Blood Glucose Tracks Using Clinical Protocols of the DirecNet Database
Abstract
This article describes a method for forming daily blood glucose (BG) tracks for diabetes mellitus patients using protocols taken from the DirecNet database. The obtained daily tracks can be used for testing mathematical models of BG regulation, verifying BG prediction algorithms, and analyzing individual trends in patient’s BG dynamics.



Measurement of the Temperature Field in a Brain Phantom with Simulated Glioblastoma in Transcranial High-Frequency Hyperthermia
Abstract
This paper presents the results of temperature shift measurements in a brain phantom based on agar gel and including elements simulating a tumor (glioblastoma) and cerebrospinal fluid for assessment of the safety of real courses of high-frequency hyperthermia using a Celsius TCS system. No “hot spots” formed at the boundary between normal brain tissue and fluid and the temperature did not excess physiological values. Higher tempera-tures were produced in the model viable tumor (glioblastoma), reaching the values required for hyperthermic radiosensitization.



The Effect of Transmitter Coil Size on the Optimal Implantation Depth of Receiver Coil in Transcutaneous Inductive Energy Transfer Systems
Abstract
The effect of patient’s individual characteristics on the output of wireless transcutaneous inductive energy transfer systems has been studied. Numerical modeling shows that small changes in the implantation depth due to patients’ individual characteristics (thickness of skin, subcutaneous fat layer, and bones) can lead to significant changes in output power and efficiency of the energy transfer. Our study shows that the effect of these changes can be compensated by optimizing the size of the external (transmitter) coil.



Hybrid Intelligent Models for Chest X-Ray Image Segmentation
Abstract
Hybrid intelligent systems allowing segments related to diagnosable diseases to be identified on chest X-ray films are presented. X-Rays were segmented by analysis of two-dimensional Fourier spectra with a sliding window. The spectrum of the sliding window was processed with sequential filters constructed on the basis of different image processing paradigms. An algorithm for tuning the filters of hybrid models is proposed, and results from segmentation of X-rays from patients with pneumonia are demonstrated.



Assessment of Treatment Efficacy in Patients with Genital Herpes in Terms of Electrical Properties of Tissues at Specific Acupuncture Points Using a Fuzzy Mathematical Model
Abstract
The classification of the stages of genital herpes is discussed on the basis of readings from acupuncture points P7 and VC7, which change their energy characteristics as the activity of genital herpes increases. Inclusion of reflex therapy methods to traditional treatment schemes was found to promote decreases in the duration of clinical episodes. A scheme for a standalone instrument based on a microcontroller with low energy consumption able to monitor the energy status of acupuncture points is described.



A System for the Differential Diagnosis of Malignant Tumors of the Adnexa of the Uterus Based on a Neural Network
Abstract
We present here the results of developing a complex method for the differential diagnosis of malignant tumors of the uterine adnexa which was used as the basis for the “Risk Ovarian Cancer v.2.2” computer system. Measures of the sensitivity and specificity of this system and the potential for its use are presented.



Low-Energy Complex Magnetotherapy in Oncology
Abstract
A new direction in magnetotherapy has developed in recent years, particularly in Russia, on the basis of Russian-manufactured magnetotherapy instruments of the “Magnitoturbotron” type; in this approach, the whole body is exposed to weak low-frequency vortex magnetic fields (VMF). One systemwide VMF magnetotherapy approach is the introduction of this treatment to regimens for the radial and restorative treatment of oncological diseases. In this regard, the effective use of weak low-frequency VMF on the patient’s body requires deeper study of both the local effects of treatment on tumors, but also the systemic reactions of the body as a whole.



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