THREE-LOCUS TLR10–TLR1–TLR6 HAPLOTYPES DISTRIBUTION IN TATARS OF THE CHELYABINSK REGION IN COMPARISON WITH THE POPULATIONS OF EURASIA
- 作者: Evdokimov A.V.1
-
隶属关系:
- Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 763-765
- 栏目: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119513
- DOI: https://doi.org/10.31857/S102872210006706-1
- ID: 119513
如何引用文章
全文:
详细
This article describes the cluster TLR10-TLR1-TLR6 haplotypes distribution features observed in Tatars of the Chelyabinsk Region. For the fi rst time in Tatars population the frequencies of three-locus haplotypes – 721A>C in TLR10 gene, 1805T>G in TLR1 gene and 745C>T in TLR6 gene – were obtained. The most similar haplotype frequencies among the world Eurasian populations were identified in Toscans and Iberians, while other Eurasian populations differed significantly from Tatars. The data obtained may be useful in the study of predictors of auto-inflammatory and infectious diseases.
作者简介
A. Evdokimov
Federal State Budgetary Educational Institution of Higher Education “Chelyabinsk State University”
编辑信件的主要联系方式.
Email: avdax@yandex.ru
candidate of biological sciences, assistant professor at the Department of microbiology, immunology and general biology of the biology faculty,
Chelyabinsk
俄罗斯联邦参考
- Barreiro L. B., Quintana-Murci L. From evolutionary genetics to human immunology: how selection shapes host defense genes. // Nature Review Genetics. – 2010. – № 11. – P. 17–30.
- Dannemann M., Andres A. M., Kelso J. Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors // The American Journal of Human Genetics. – 2016. – № 98. – P. 22–33.
- Casanova J.-L., Laurent A., Quintana-Murci L. Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics // Annu. Rev. Immunol. – 2011. – № 29. – P. 447–491.
- Балановская Е. В., Балановский О. П. Русский генофонд на Русской равнине. – Москва: Луч, 2007. – 416 с.
- Чернова М. С. Иммуногенетический профиль популяций Челябинской области (русские, татары, башкиры, нагайбаки) в структуре мировых популяций: автореф. дис. … канд. биол. наук (14.03.09) / Чернова Мария Сергеевна. – Челябинск, 2014. – 22 с.
补充文件
