Synthesis of glutaryl-containing derivatives of GRGD and KRGD peptides


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Аннотация

New derivatives of tetrapeptides GRGD (Gly-Arg(Pbf)-Gly-Asp(OMe)-OMe) and KRGD (Boc-Lys-Arg(Pbf)-Gly-Asp(OMe)-OMe) containing a glutaric acid fragment as a linker were synthesized. The linker provides the possibility for binding these derivatives to other biologically active molecules or nanoparticles.

Авторлар туралы

A. Demin

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: demin@ios.uran.ru
Ресей, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990

A. Vakhrushev

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: demin@ios.uran.ru
Ресей, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990

A. Tumashov

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Institute of Natural Sciences and Mathematics, Ural Federal University

Email: demin@ios.uran.ru
Ресей, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002

V. Krasnov

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: demin@ios.uran.ru
Ресей, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990

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