Synthesis of glutaryl-containing derivatives of GRGD and KRGD peptides


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New derivatives of tetrapeptides GRGD (Gly-Arg(Pbf)-Gly-Asp(OMe)-OMe) and KRGD (Boc-Lys-Arg(Pbf)-Gly-Asp(OMe)-OMe) containing a glutaric acid fragment as a linker were synthesized. The linker provides the possibility for binding these derivatives to other biologically active molecules or nanoparticles.

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A. Demin

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

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Email: demin@ios.uran.ru
俄罗斯联邦, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990

A. Vakhrushev

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: demin@ios.uran.ru
俄罗斯联邦, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990

A. Tumashov

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Institute of Natural Sciences and Mathematics, Ural Federal University

Email: demin@ios.uran.ru
俄罗斯联邦, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002

V. Krasnov

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: demin@ios.uran.ru
俄罗斯联邦, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990

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