Email this article Synthesis and antimycobacterial activity of N-isonicotinoyl-N′-alkylideneferrocenecarbohydrazides
- Authors: Nikulin R.S.1,2, Rodionov A.N.1, Babusenko E.S.2, Babin V.N.1, Kovalenko L.V.2, Belousov Y.A.1, Kulikov V.N.1,2
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Affiliations:
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- Issue: Vol 66, No 6 (2017)
- Pages: 1122-1125
- Section: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/240884
- DOI: https://doi.org/10.1007/s11172-017-1864-y
- ID: 240884
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Abstract
Acylation of ferrocenoylhydrazones with isonicotinoyl chloride hydrochloride in pyridine was used to obtain a number of new N-isonicotinoyl-N′-ylideneferrocenecarbohydrazides in 50–95% yields. The obtained compounds were characterized by NMR and IR spectroscopy and mass-spectrometry. Some of the obtained compounds were found to exhibit pronounced antimycobacterial activity against the Mycobacterium rubrum strain and to have no toxicity with respect to the P. aeruginosa, E. coli, S. aureus, B. subtilis, and C. albicans strains.
About the authors
R. S. Nikulin
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences; D. I. Mendeleev University of Chemical Technology of Russia
Email: belur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991; 9 Miusskaya pl., Moscow, 125047
A. N. Rodionov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: belur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
E. S. Babusenko
D. I. Mendeleev University of Chemical Technology of Russia
Email: belur@ineos.ac.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047
V. N. Babin
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: belur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
L. V. Kovalenko
D. I. Mendeleev University of Chemical Technology of Russia
Email: belur@ineos.ac.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047
Yu. A. Belousov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Author for correspondence.
Email: belur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
V. N. Kulikov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences; D. I. Mendeleev University of Chemical Technology of Russia
Author for correspondence.
Email: kulikov_v_n@mail.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991; 9 Miusskaya pl., Moscow, 125047
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