Email this article Synthesis of glutaryl-containing derivatives of GRGD and KRGD peptides
- Authors: Demin A.M.1, Vakhrushev A.V.1, Tumashov A.A.1,2, Krasnov V.P.1
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Affiliations:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Institute of Natural Sciences and Mathematics, Ural Federal University
- Issue: Vol 68, No 12 (2019)
- Pages: 2316-2324
- Section: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/243565
- DOI: https://doi.org/10.1007/s11172-019-2705-y
- ID: 243565
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Abstract
New derivatives of tetrapeptides GRGD (Gly-Arg(Pbf)-Gly-Asp(OMe)-OMe) and KRGD (Boc-Lys-Arg(Pbf)-Gly-Asp(OMe)-OMe) containing a glutaric acid fragment as a linker were synthesized. The linker provides the possibility for binding these derivatives to other biologically active molecules or nanoparticles.
About the authors
A. M. Demin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: demin@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990
A. V. Vakhrushev
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: demin@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990
A. A. Tumashov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Institute of Natural Sciences and Mathematics, Ural Federal University
Email: demin@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002
V. P. Krasnov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: demin@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990
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